Spinal neuroplastic changes in lower urinary tract irritatioin, special reference to peripheral nerve growth factor and spinal protooncogene expression
下尿路刺激引起的脊髓神经塑性改变,特别参考周围神经生长因子和脊髓原癌基因的表达
基本信息
- 批准号:12671519
- 负责人:
- 金额:$ 2.43万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2000
- 资助国家:日本
- 起止时间:2000 至 2001
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1) There was close similarity of spinal distribution of c-Fos expression and dermatome distribution of plasma extravasation after nociceptive stimulation of the bladder, prostate and external sphincter. Under the nociceptive stimulation , there would be close similarity in nocisensitive afferent pathways among these organs.2) Chronic bladder irritation induced upregulation of spinal substance P and NK1-receptor immuno-positive areas. Upregulation of transmission of substance P- NK1 system after chronic bladder irritation.3) Acute nociceptive stimulation of the prostate resulted in upregulation of spinal substance P immunoreactivity. This enhancement is weakened by administration of an alpha-blocking agent. Substance P appeared to play an important role in nociceptive transmission from the prostate. Sympathetic nerve system could influence such a nociceptive transmission.4) Electrical stimulation from the SI foramen could mask the c-Fos expression after nociceptive lower urinary tract stimulation. It appeared possible sacral nerve stimulation can improve lower urinary tract symptoms through this mechanism.
1)伤害性刺激膀胱、前列腺和外括约肌后,c-Fos表达的脊髓分布与血浆渗出的皮肤组分布相似。在伤害性刺激下,各器官的伤害性传入通路具有相似性。2)慢性膀胱刺激引起脊髓P物质和NK1受体免疫阳性区上调。慢性膀胱刺激后P物质-NK1系统传递上调。3)前列腺急性伤害性刺激导致脊髓P物质免疫反应上调。这种增强作用因使用阿尔法阻滞剂而减弱。P物质似乎在来自前列腺的伤害性信息传递中起着重要作用。交感神经系统可影响这种伤害性信息的传递。4)下尿路伤害性刺激后,SI孔的电刺激可抑制c-Fos的表达。这可能是通过这一机制来改善下尿路症状的。
项目成果
期刊论文数量(17)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Ishigooka M.: "Spinal NK1 receptor is upregulated after chronic bladder irritation"PAIN. 93(1). 43-50 (2001)
Ishigooka M.:“慢性膀胱刺激后脊髓 NK1 受体上调”PAIN。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Ishigooka M, Nakada T, Hashimoto T, Zermann DH, Schmidt RA: "C-Fos expression in the spinal cord after acute sacral segmental nerve stimulation"Neurourology and Urodynamics. (in press). (2002)
Ishigooka M、Nakada T、Hashimoto T、Zermann DH、Schmidt RA:“急性骶节段神经刺激后脊髓中的 C-Fos 表达”神经泌尿学和尿动力学。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Ishigooka M.: "Spinal substance P immunoreactivity is enhanced by acute chemical stimulation of the rat prostate"UROLOGY. 59(1). 139-144 (2001)
Ishigooka M.:“通过对大鼠前列腺的急性化学刺激增强脊髓 P 物质免疫反应性”泌尿学。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Ishigooka M: "Spinal substance P Immunoreactivity is enhanced by acute chemical stimulation of the rat prostate"UROLOGY. 59. 139-144 (2002)
Ishigooka M:“通过对大鼠前列腺的急性化学刺激增强脊髓 P 物质的免疫反应性”泌尿学。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Ishigooka M, Zermann DH, Doggweiler R, Schmidt RA: "Similarity of distributions of spinal c-Fos and plasma extravasation after acute chemical irritation of the bladder and the prostate."J Urol. 164. 1751-6 (2000)
Ishigooka M、Zermann DH、Doggweiler R、Schmidt RA:“膀胱和前列腺急性化学刺激后脊髓 c-Fos 分布和血浆外渗的相似性。”J Urol。
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- 影响因子:0
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