Clinical Evalution of Antnior Mandibular Positioning Device for Patients with Obstructive Sleep Apnea

前下颌定位装置治疗阻塞性睡眠呼吸暂停的临床评价

• 批准号: 12671897
• 负责人: MASUMI Shin-ichi
• 金额: $ 1.98万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671897/
• 关键词: Obstructive Sleep Apnea; Sleep Splint; Polysomnography; Cliflical Evaluation; スプリント

The purpose of this study is to evaluate two fabrication methods (direct method, indirect method) of a simple AMP and evaluate its treatment effect for the patients with OSAS by using polysomnography (PSG)and Epworth sleepiness scale (ESS) bifore and after AMP therapy.Thera Snore TM (Distar) was used as AMP in this:study. Fabrication method of this AMP was indicated a direct method by manufacturer. We designed a inderect methoc and compared with a direct mothod. To evaluate the treatment eggect of this AMP five OSAS patients (4 males and 1 female) were involved. Mean age was 59.8 Years and body mass index (BMI) was 26.1. Each patient underwent PSG and ESS befor and after AMP therapy and evaluated about apnea index (AI),apnea-hypopnea index (AHI), Lowest SpO2, arousal index, and ESS.Indirect fabrication method was better than direct method from the viewpoint of the fitness and the protection of mucous membrane from scald. AI was improved from 5.5 +/- 4.04 to 2.3 +/- 3.86. AHI was improved 20.8 +/- 14.99 to 8.8 +/- 9.04. Lowest SpO2 was improved from 8l.0 +/- 9.08 to 86.6 +/ -6.73 %. Arousal index improved 31.6 +/- 10.26 to 25.5 +/- 10.37. ESS was improved from 10.6 +/- 1.95 to 6.0 +/- 3.08.It was suggested hat the indirect method was better than the direct method for fabricating the AMP which used in this study. It was also suggested that this AMP was useful for the treatment of the patients with OSAS.

本研究旨在评价两种简易AMP的制作方法（直接法和间接法），并通过多导睡眠图（PSG）和埃普沃思嗜睡量表（ESS）评价AMP治疗OSAS患者前后的疗效。该AMP的制造方法由制造商指示为直接方法。设计了一种间接法，并与直接法进行了比较。为了评价AMP的治疗效果，5例OSAS患者（4例男性和1例女性）参与了研究。平均年龄为59.8岁，体重指数（BMI）为26.1。在AMP治疗前后分别行PSG和ESS检查，评估呼吸暂停指数（AI）、呼吸暂停低通气指数（AHI）、最低血氧饱和度（LSpO 2）、觉醒指数（Ausarindex）和ESS，从适应性和保护粘膜免受损伤的角度考虑，间接法优于直接法。AI从5.5 +/- 4.04改善至2.3 +/- 3.86。AHI改善20.8 +/- 14.99至8.8 +/- 9.04。最低SpO 2从81.0 +/- 9.08改善至86.6 +/-6.73%。唤醒指数从31.6 +/- 10.26提高到25.5 +/- 10.37。ESS由10.6 ± 1.95提高到6.0 ± 3.08。间接法制备AMP优于直接法。本研究还表明，该AMP对OSAS患者的治疗有一定的临床意义。

项目成果

Masumi S. et al: "Dental Approach for tiie Patients with Obstructive Sleep Apnea Syndrome"J kitakyushu Med Eng Conf. (now printing). (2002)

Masumi S. 等人：“阻塞性睡眠呼吸暂停综合征患者的牙科方法”J kitakyushu Med Eng Conf。

鱒見進一ほか: "閉塞型睡眠時無呼吸症候群患者に対する歯科的対応"北九州医工学術者協会誌. 13. (2002)

Shinichi Masumi等：“阻塞性睡眠呼吸暂停综合征患者的牙科治疗”北九州医学工程师协会杂志13。（2002年）

鱒見進一 ほか: "閉塞型睡眠時無呼吸症候群患者に対する歯科的対応"北九州医工学術者協会誌. 13. (2002)

Shinichi Masumi等：“阻塞性睡眠呼吸暂停综合征患者的牙科治疗”北九州医学工程师协会杂志13。（2002年）