Clinical Evalution of Antnior Mandibular Positioning Device for Patients with Obstructive Sleep Apnea

本研究旨在通过多导睡眠图(PSG)和Epworth嗜睡量表(ESS)评价两种简易AMP制作方法(直接法、间接法)对阻塞性睡眠呼吸暂停综合征(OSAS)患者的治疗效果。该AMP的制备方法被制造商指明为一种直接方法。我们设计了一种间接方法，并与直接方法进行了比较。5例OSAS患者(男4例，女1例)为评价该AMP的治疗效果。平均年龄59.8岁，体重指数(BMI)26.1。在AMP治疗前后分别进行PSG和ESS检查，评价呼吸暂停指数(AI)、呼吸暂停低通气指数(AHI)、最低血氧饱和度(SpO2)、觉醒指数和ESS。从黏膜的适合性和对烫伤的保护作用来看，间接法优于直接法。AI从5.5+/-4.04提高到2.3+/-3.86。AHI由20.8+/-14.99提高至8.8+/-9.04。最低血氧饱和度由治疗前的81.0±9.08提高到86.6±6.73%。觉醒指数提高了31.6+/-10.26，达到25.5+/-10.37。ESS由10.6+/-1.95提高到6.0+/-3.08，间接法制备AMP优于直接法制备AMP。提示该药对治疗阻塞性睡眠呼吸暂停低通气综合征有一定的应用价值。

The purpose of this study is to evaluate two fabrication methods (direct method, indirect method) of a simple AMP and evaluate its treatment effect for the patients with OSAS by using polysomnography (PSG)and Epworth sleepiness scale (ESS) bifore and after AMP therapy.Thera Snore TM (Distar) was used as AMP in this:study. Fabrication method of this AMP was indicated a direct method by manufacturer. We designed a inderect methoc and compared with a direct mothod. To evaluate the treatment eggect of this AMP five OSAS patients (4 males and 1 female) were involved. Mean age was 59.8 Years and body mass index (BMI) was 26.1. Each patient underwent PSG and ESS befor and after AMP therapy and evaluated about apnea index (AI),apnea-hypopnea index (AHI), Lowest SpO2, arousal index, and ESS.Indirect fabrication method was better than direct method from the viewpoint of the fitness and the protection of mucous membrane from scald. AI was improved from 5.5 +/- 4.04 to 2.3 +/- 3.86. AHI was improved 20.8 +/- 14.99 to 8.8 +/- 9.04. Lowest SpO2 was improved from 8l.0 +/- 9.08 to 86.6 +/ -6.73 %. Arousal index improved 31.6 +/- 10.26 to 25.5 +/- 10.37. ESS was improved from 10.6 +/- 1.95 to 6.0 +/- 3.08.It was suggested hat the indirect method was better than the direct method for fabricating the AMP which used in this study. It was also suggested that this AMP was useful for the treatment of the patients with OSAS.