Development and dental application of novel low viscous monomers

合成了具有相对低粘度的新型单体，并对其进行了研究，以准确确定其作为牙科复合树脂或粘合剂的基础单体的可能性。作为骨架结构中心的碳原子数比双-GMA少一个或两个的单体，以及双酚AD环氧单体的甲基丙烯酸酯衍生物，1，合成了1-双[4-（2-羟基-3-甲基丙烯酰氧基丙氧基）苯基]乙烷（单体1）和双[4-（2-羟基-3-甲基丙烯酰氧基丙氧基）苯基]甲烷（单体2）。测定了单体的粘度，研究了单体光固化所得聚合物的力学性能，并研究了由这些单体制备的混杂填充光固化复合树脂的一些力学性能。结果表明：1）单体1和2的粘度明显小于bis-GMA; 2）单体1和2易于用光引发剂聚合; 3）由单体1得到的聚合物强度与由bis-GMA和TEGDMA混合单体得到的聚合物强度基本相同; 4）得到了含杂化填料的光固化复合树脂。实验复合树脂的力学性能与bis-GMA和TEGDMA共聚单体的力学性能相当，表明单体1有望作为牙科复合树脂或牙科粘接剂的基础单体。

Novel monomers with relatively low viscosity were synthesized and investigated to accurate the possibility of the dental use as a base monomer for composite resin or adhesive cement. Such monomers have no need to use diluent monomers which possibly cause to weaken over all mechanical properties of cured materials.As the monomers whose center of skeletal structures have one or two less carbon than bis-GMA, and methacrylate derivatives of bis-phenol AD epoxy monomer, 1,1-bis[4-(2-hydroxy-3-methacryloyloxypropoxy)-phenyl]ethane (monomer 1) and bis-[4-(2-hydroxy-3-methacryloyloxy-propoxy)phenyl]methane (monomer 2) were synthesized. The viscosities of the monomers were measured, then mechanical properties of the polymers obtained from light curing of the monomers were investigated and some mechanical properties of hybrid filled light curing composite resins made from these monomers were also investigated. The following conclusions were drawn.1)The viscosities of monomer 1 and 2 were relatively significantly smaller than that of bis-GMA.2)Monomer 1 and 2 can be polymerized easily by usual light induced initiators.3)The polymer obtained from the monomer 1 has almost the same strength of that obtained from bis-GMA and TEGDMA monomer mixture.4)The light curing composite resins containing hybrid fillers were obtained.5)The mechanical properties of the experimental composite resins, were the same level as those of bis-GMA and TEGDMA comonomer.From above conclusions, monomer 1 seemed to hold great promise for the use of the base monomer of dental composite resin or dental adhesive cements.