Basic Study for Health Control by Human Circadian Rhythm of Urinary Fluoride Excretion

用尿氟排泄规律研究了8名健康男性在禁食和进食条件下的氟代谢。禁食40小时，自由饮水，进食4天，每隔2小时采集尿样，测定F、Na、K、Cl、Ca、Mg、P和肌酸(Cre)。生物节律的计算结果用余弦量计算方法进行分析。在禁食条件下，这些成分没有明显的生物节律。在喂养条件下，发现了三个节律组：组1：Na、K和Cl，组2：Ca、Mg、P和Cre，组3：F。这些结果表明，F与所研究的其他尿组分的代谢行为存在显著差异。

Fluoride (F) metabolism in eight healthy men was studied by urinary excretion patterns under fasting and feeding conditions. The subjects in the fasting experiment had no food for 40 hr and drank water ad libitum, while those in the feeding experiment ate space food for 4 days.Urine samples were taken at 2-hr intervals during waking hours for determination of F, Na, K, Cl, Ca, Mg, P, and creatnine (Cre). Results were analyzed for biorhythm by the cosinor computation method. Under fasting conditions, no biorhythm was apparent in these components. Under feeding conditions, three rhythm groups were identified : Group 1 : Na, K, and Cl ; Group 2 : Ca, Mg, P, and Cre ; and Group 3 : F. These results indicate marked differences in metabolic be-havior between F and the other urinary components under study.