ANTIBIOTICS CIRCURATION AND BIOLOGICAL ACCUMURATION IN SEMIENCLOSED SEA

本文测定了养殖场海水和底泥中两种抗生素（ABPC和OTC）的浓度。从越南红树林地区的虾池中提取甲氧苄啶（TMP）、磺胺甲恶唑（SMX）、诺氟沙星（NFXC）和恶喹酸（OXLA）等4种抗生素，并测定其浓度。水体中AMP和OTC浓度波动范围分别为0.56-1.4ppb和0.25-4.9ppb;养殖区底泥中AMP和OTC浓度波动范围分别为15- 25 μ g/g干泥和0.15- 0.35 μ g/g干泥。在10 cm深的淤泥中，AMP和OTC的累积量分别为8 t和80 kg。其浓度C（t）可用指数函数C（t）= Ciexp（-α t）表示，其中t为时间，α受初始浓度的影响 关于我们 浓度，C_i.低浓度的OTC容易被降解，但高浓度超过10 mM时，尤其是AMP，降解困难。4）浮游生物在含有OTC的1/2 F培养基中生长，OTC浓度越高，浮游生物的生长速度越快，OTC向浮游生物细胞中的积累速度也越快。5）越南虾塘水中的TMP浓度在地表水中为0.3〜1.1ppm，6）越南虾池1g底泥中TMP、SMX、NFXC、OXLA的累积量分别为0.02 ~ 0.13mg、0.01 ~ 0.08mg、0.1 ~ 2.6mg、0.1mg。水体中抗生素含量高，在虾池底泥中积累严重; 7）海水中抗生素含量高，在虾池底泥中积累严重，降解程度低。抗生素刺激了浮游生物的生长，抗生素在浮游生物体内积累。在这些抗生素污染的环境中，产生了大量的耐药细菌，每年都有白色斑点综合征病毒（WSSV）、黄头虾病毒（YHSV）和牛磺酸综合征病毒（TSSV）等对虾疾病爆发。少

The concentrations of two kinds of antibiotics (ABPC and OTC) in seawater and bottom mud were measured in the fisheries ground. Other four kinds of antibiotics (trimethoprim (TMP), sulfamethoxazole (SMX), norfoxacin (NFXC), oxolinic acid (OXLA)) were extracted from water and bottom mud in Vietnam shrimp rearing ponds developed in the mangrove area and their concentrations were measured. The degradation rate of antibiotics under UV and its absorption and accumulation in plankton were also measured.1) AMP and OTC concentration in water were fluctuated 0.56-1.4ppb and 0.25-4.9ppb, respectively.2) AMP and OTC concentration in bottom mud in fish culture area were fluctuated 15-25ug/1g dry mud and 0.15-0.35ug/1g dry mud, respectively. Accumulated AMP and OTC in 10cm mud depth in Uranouchi Bay were 8ton and 80kg, respectively.3) Antibiotics were degraded under UV. Its concentration C(t) was indicated by exponential function like as C(t)=C_iexp(-α t), where t is time, α is effected by initial … More concentration, C_i. Low concentration OTC is easy to be degraded, but difficult in high concentration of over lOmM, particularly AMP.4) Plankton grew in the 1/2 F medium with OTC, the higher the OTC concentration, the higher the growth rate of plankton and accumulation rate of OTC into plankton cells.5) Concentration of TMP in Vietnam shrimp pond water was 0.3〜1.1ppm in the surface water, 0.3〜2.1ppm in bottom water, Maximum SMX was 1.8〜5.6ppm, maximum NFXC was 1〜4ppm, OXLA was 0.5〜1.8ppm.6) TMP was accumulated at 0.02〜0.13mg, SMX was 0.01〜0.08mg, NFXC Was 0.1〜2.6mg, OXLA was 0.1mg in bottom wet mud of 1g in Vietnam shrimp pond. Antibiotics were terrible highly contained in water and accumulated in bottom mud of shrimp pond.7) Low degradation antibiotics were contained highly in the seawater and accumulated in the bottom mud. Antibiotics stimulated the growth of plankton, and antibiotics were accumulated in plankton. Antibiotic-resistant bacteria appear in these antibiotic contaminated environments, and shrimp diseases such as WSSV (White spot syndrome shrimp virus), YHSV (Yellow head shrimp virus) and TSSV (Taurin syndrome virus) breakout every year. Less