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Effects of arterial blood volume, pulse pressure, and mean arterial pressure on normalized pulse volume

动脉血量、脉压和平均动脉压对标准化脉搏量的影响

基本信息

批准号：
13610092
负责人：
SAWADA Yukihiro
金额：
$ 1.28万
依托单位：
Sapporo Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

项目摘要

A near-infrared finger photoplethysmogram adopting a wavelength of 810 nm provides for the pulsatile ac component (ΔI) superimposed on the transmitted dc components in a normal (I : tissue plus blood) and an ischaemic circulatory state (I_t : tissue only). Simultaneous recording of finger blood pressure provides for the distending pulse (PP) and mean blood pressure (MBP). Based on the Lambert Beer's law, indices of the arterial compliance (CI ; =ΔI/I/PP) is advocated for the finger vasculature. We introduced the exponential pressure-volume model ( V=a-b^*exp(-nP)) and examined arterial blood volume, PP, and transmural pressure on the model parameters (a,b,n). Experiment 1 : Twelve female subjects underwent immersions of the contralateral hand in water at two different temperatures (44℃, 22℃). CI calculated at 90mmHg (CI90) of linear regression between logCI and MBP decreased significantly during 22℃ condition. Experiment 2 : The functional relationship to the transmural pressure for CI was examined using finger-occlusion during mental arithmetics in sixteen females and reactive hyperaemia in five. Logarithmically transformed CI was linearly associated with the transmural pressure. Three parameters (a,b,n) of the exponential P-V relationship were systematically modified by mental arithmetics and reactive hyperaemia. Experiment 3 : Age-associated differences in parameter a, b, and n were examined during resting condition between 30 young students and 12 middle aged workers. In middle aged subjects, the model fitness deteriorated and only the parameter n was lowered compared with young student.We advocated the exponential P-V model for finger vasculature and developed the new analytical method for the elastic property of finger artery. Experimental findings supported the validity and usefulness of our model. Structural vascular change due to aging and functional vasoconstriction proved to be separated by different changes in model parameters.

采用810 nm波长的近红外手指光体积图提供了在正常(I：组织加血液)和缺血循环状态(I_t：仅组织)下叠加在传输的DC分量上的搏动性交流分量(ΔI)。手指血压的同时记录提供了扩张脉搏(PP)和平均血压(MBP)。根据朗伯-比尔定律，提出手指血管顺应性指数(CI；=ΔI/I/PP)。我们引入了指数压力-容量模型(V=a-b^*exp(-np))，并检验了动脉血容量、脉压和跨壁压对模型参数(a，b，n)的影响。实验一：12名女性受试者在两种不同温度(44℃和22℃)的水中浸泡对侧手。在22℃状态下，按LogCI与平均动脉压线性回归的90 mm HgCI计算的CI显著降低。实验2：16名女性和5名反应性充血患者在心算过程中用手指遮盖法检测CI的功能与跨壁压力的关系。经对数变换后的CI与跨壁压呈线性相关。用心算和反应性充血对指数P-V关系的三个参数(a，b，n)进行了系统的修正。实验三：考察了30名青年学生和12名中年工人在休息状态下a、b、n参数的年龄差异。中年受试者的模型适合度比青年受试者差，只有参数n比青年受试者低。我们倡导手指血管的指数P-V模型，发展了手指动脉弹性特性的新的分析方法。实验结果支持了该模型的有效性和实用性。衰老引起的结构性血管改变和功能性血管收缩被证明通过模型参数的不同变化而分离。