Quasi tissue engineering of Process for Fabrication of Multi-Functional Composites

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The number of diseases relating to the bones, such as osteoporosis, increases with aging in the society year by year. According to the report on an investigation of the Ministry of Health, Labor and Welfare, the number of patients who is diagnosed, as osteoporosis will be approximately 12.5 million in 2010 and approximately 80% are women among these patients. Thus the osteoporosis may be regarded as a national disease in Japan that faces the aging society.In the twenty-first century, advanced needs will arise for the higher performance artificial bones. The requirement for the applied parts, however, may be different from bone to bone, because the number of bones in the human body is as large as 206. The functions that are required to substitute the materials for human hard tissues are directed not only toward the biocompatibility/bioaffinity but also toward the high mechanical strength, high fracture toughness, and low Young's modulus. The present project is aimed at the fabrications of high loading parts (hip joints) and low loading parts (substitute materials for bones). Among the present subjects listed below, Subject (1) includes the fabrication of the biocompatible and high loading parts, whereas Subjects (2) and (3) include the fabrication of low loading parts :(1) Coating process and evaluation(2) Formation process of self-restoration function(3) Processing of bone-like composites and evaluation