Deciphering molecular genetic mechanisms underlying chromatin interactions

破译染色质相互作用的分子遗传机制

• 批准号: DE220101210
• 负责人: Dr Hamid Alinejad Rokny
• 金额: $ 32.49万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220101210
• 关键词: Deciphering; molecular; genetic; mechanisms; underlying

This project aims to generate the high confidence map of enhancer-promoter links in 61 tissues and cells through robust integration of novel machine learning tools with genomic and epigenomic datasets. Understanding which key elements in the genome may be important to fine-tune gene expression is essential for understanding biological pathways. The expected outcomes include i) New tools to robustly identify true chromatin pairs; ii) Comperehensive maps of regulatory interactomes in 61 tissues & cells, which will provide a roadmap for interpreting & prioritising noncoding variants. This should provide significant benefit to Australia's capacity for cutting-edge genomics research through fundamental understanding of gene regulation mechanism.

该项目旨在通过新型机器学习工具与基因组和表观基因组数据集的强大整合，在61种组织和细胞中生成增强子-启动子连接的高置信度图谱。了解基因组中的哪些关键元件可能对微调基因表达很重要，这对于理解生物学途径至关重要。预期成果包括：i）稳健识别真正染色质对的新工具; ii）61种组织和细胞中调控相互作用组的综合图谱，这将为解释和优先考虑非编码变体提供路线图。 这将通过对基因调控机制的基本理解，为澳大利亚进行尖端基因组学研究的能力提供重大益处。