Magnetic resonance imaging of bound water in biological systems and its clinical applications.

生物系统中结合水的磁共振成像及其临床应用。

• 批准号: 13670039
• 负责人: ERA Seiichi
• 金额: $ 0.38万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670039/
• 关键词: free water; unfrozen water; restricted water; synthetic copolymer gels; MRI; DSC; magnetization transfer

A prospective study was performed to investigate the correlations between saturation transfer ratio (STR) and histological parameters of invasive ductal carcinomas in human breast. The histological parameters investigated were the extent of fibrosis in the intracellular matrix, dysplastic changes of nuclei, and mitotic index. Twenty-seven patients with breast carcinoma were examined using an off-resonance saturation pulse in conjunction with conventional field-echo T_1-weighted imaging at frequency offsets of 448 Hz and 1200 Hz from water resonance. The values of STR at frequency offset of 1200 Hz (STR_<1200>) increased from non-scirrhous carcinoma to scirrhous carcinoma. Although STR_<1200> showed correlation with the extent of fibrosis in the intracellular matrix, they did not correlate with the dysplastic changes of nuclei or mitotic index. On the other hand, the values of STR at frequency offset of 448 Hz (STR_<448>) demonstrated close correlation to dysplastic changes of nuclei and mitotic index. STR_<1200> correlates with the structural characteristics and STR_<448> correlates with the nature of malignant cells with regard to nuclear dysplasia and mitotic potential.

本研究旨在探讨乳腺浸润性导管癌的饱和转移率（STR）与组织学参数的关系。研究的组织学参数为细胞内基质纤维化程度、细胞核发育异常改变和有丝分裂指数。27例乳腺癌患者采用非共振饱和脉冲与常规场回波t_1加权成像相结合的方法进行检查，频率偏移为448 Hz和1200 Hz。在1200hz频偏处（STR_<1200>），从非黏液癌到黏液癌的STR值增加。虽然STR_<1200>与细胞内基质纤维化程度相关，但与细胞核发育异常或有丝分裂指数无关。另一方面，频率偏移448 Hz时的STR值（STR_<448>）与细胞核发育异常和有丝分裂指数密切相关。STR_<1200>与恶性细胞的结构特征相关，STR_<448>与细胞核发育不良和有丝分裂潜能相关。

项目成果

S.Matsushima, A.Takasu, Y.Inai, T.Hirabayashi, S.Era, M.Sogami, F.Sasaki, H.Ohsaki, Y.Kinisada: "Equivalent cross-relaxation rate imaging in the synthetic copolymer gels and invasive ductal carcinomas of the breast"Magnetic Resonance Imaging. 20. 285-293

S.Matsushima、A.Takasu、Y.Inai、T.Hirabayashi、S.Era、M.Sogami、F.Sasaki、H.Ohsaki、Y.Kinisada：“合成共聚物凝胶和侵入性凝胶中的等效交叉弛豫率成像

T.Negawa, S.Mizuno, T.Hayashi, H.Kuwata, M.Tomida, H.Hoshi, S.Era, K.Kuwata: "M pathway and areas 44 and 45 are involved in stereoscopic recognition based on binocular disparity"Japanese Journal of Physiology. 52. 191-198 (2002)

T.Nekawa、S.Mizuno、T.Hayashi、H.Kuwata、M.Tomida、H.Hoshi、S.Era、K.Kuwata：“M 通路以及区域 44 和 45 参与基于双眼视差的立体识别”

M. Sogami, N. Uyesaka, S. Era, K. Kato: "Saturation transfer in human red blood cells with normal and unstable hemoglobin"NMR in Biomedicine. 16. 1-11 (2003)

M. Sogami、N. Uyesaka、S. Era、K. Kato：“正常和不稳定血红蛋白的人红细胞中的饱和转移”生物医学中的 NMR。

T.Hayashi, H.Imai, K.Kuwata, M.Sogarni, S.Era: "The importance of sample preservation temperature for analysis of the redox state of serum albumin"Clinica Chimica Acta. 316. 175-178 (2002)

T.Hayashi、H.Imai、K.Kuwata、M.Sogarni、S.Era：“样品保存温度对于分析血清白蛋白氧化还原状态的重要性”Clinica Chimica Acta。

M.Sogami, N.Uyesaka, S.Era, K.Kato: "Saturation transfer in human red blood cells with normal and unstable hemoglobin"NMR in Biomedicine. 16. 1-11 (2003)

M.Sogami、N.Uyesaka、S.Era、K.Kato：“正常和不稳定血红蛋白的人红细胞中的饱和转移”生物医学中的 NMR。