Magnetic resonance imaging of bound water in biological systems and its clinical applications.

本研究旨在探讨乳腺浸润性导管癌的饱和转移率（STR）与组织学参数的关系。研究的组织学参数为细胞内基质纤维化程度、细胞核发育异常改变和有丝分裂指数。27例乳腺癌患者采用非共振饱和脉冲与常规场回波t_1加权成像相结合的方法进行检查，频率偏移为448 Hz和1200 Hz。在1200hz频偏处（STR_<1200>），从非黏液癌到黏液癌的STR值增加。虽然STR_<1200>与细胞内基质纤维化程度相关，但与细胞核发育异常或有丝分裂指数无关。另一方面，频率偏移448 Hz时的STR值（STR_<448>）与细胞核发育异常和有丝分裂指数密切相关。STR_<1200>与恶性细胞的结构特征相关，STR_<448>与细胞核发育不良和有丝分裂潜能相关。

A prospective study was performed to investigate the correlations between saturation transfer ratio (STR) and histological parameters of invasive ductal carcinomas in human breast. The histological parameters investigated were the extent of fibrosis in the intracellular matrix, dysplastic changes of nuclei, and mitotic index. Twenty-seven patients with breast carcinoma were examined using an off-resonance saturation pulse in conjunction with conventional field-echo T_1-weighted imaging at frequency offsets of 448 Hz and 1200 Hz from water resonance. The values of STR at frequency offset of 1200 Hz (STR_<1200>) increased from non-scirrhous carcinoma to scirrhous carcinoma. Although STR_<1200> showed correlation with the extent of fibrosis in the intracellular matrix, they did not correlate with the dysplastic changes of nuclei or mitotic index. On the other hand, the values of STR at frequency offset of 448 Hz (STR_<448>) demonstrated close correlation to dysplastic changes of nuclei and mitotic index. STR_<1200> correlates with the structural characteristics and STR_<448> correlates with the nature of malignant cells with regard to nuclear dysplasia and mitotic potential.