Elucidating ATPase function during NLRP3 inflammasome assembly

人类和动物不断暴露于微生物，这些微生物栖息在外部环境以及皮肤和肠道等体表。然而，我们能够与这些微生物共存，因为我们的免疫系统保护我们免受这些日常接触。这项提案将揭示一种名为NLRP 3的重要免疫蛋白如何感知微生物和其他生理过程。当NLRP 3感知到这些因子并被激活时，它会诱导信使物质的释放，以提醒其他免疫细胞。这项研究将提供动物如何与微生物正常共存的基础知识。

Humans and animals are constantly exposed to microbes, which inhabit their external environment as well as body surfaces such as the skin and gut. We are, however, able to co-exist with these microbes, because our immune system protects us from these everyday encounters. This proposal will reveal how an important immune protein called NLRP3 senses microbes and other physiological processes. When NLRP3 senses such factors and is activated, it induces the release of messenger substances to alert other immune cells. This research will deliver fundamental knowledge of how animals normally co-exist with microbes.