Elucidating ATPase function during NLRP3 inflammasome assembly

阐明 NLRP3 炎性体组装过程中 ATP 酶的功能

• 批准号: DE220100823
• 负责人: Dr Stefan Emming
• 金额: $ 31.87万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220100823
• 关键词: Elucidating; ATPase; function; during; NLRP3

Humans and animals are constantly exposed to microbes, which inhabit their external environment as well as body surfaces such as the skin and gut. We are, however, able to co-exist with these microbes, because our immune system protects us from these everyday encounters. This proposal will reveal how an important immune protein called NLRP3 senses microbes and other physiological processes. When NLRP3 senses such factors and is activated, it induces the release of messenger substances to alert other immune cells. This research will deliver fundamental knowledge of how animals normally co-exist with microbes.

人类和动物经常接触到微生物，这些微生物生活在他们的外部环境以及皮肤和肠道等身体表面。然而，我们能够与这些微生物共存，因为我们的免疫系统保护我们免受这些日常接触的影响。这项提议将揭示一种名为NLRP3的重要免疫蛋白如何感知微生物和其他生理过程。当NLRP3感觉到这些因素并被激活时，它会诱导信使物质的释放，以警告其他免疫细胞。这项研究将提供有关动物通常如何与微生物共存的基础知识。