Effects of atrial muscle structure on the initiation mechanism of atrial fibrillation and its drug therapy
心房肌结构对心房颤动发生机制的影响及药物治疗
基本信息
- 批准号:13670083
- 负责人:
- 金额:$ 2.62万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2001
- 资助国家:日本
- 起止时间:2001 至 2002
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In isolated arterially perfused canine atria, transmural repolarization gradients were observed using high resolution optical mapping techniques to measure action potentials from the epicardial and endocardial surface on the right at rial free wall. These are performed during control conditions, during electrical stimulation of the fat pad at the right pulmonary vein-atrial junction (i.e. intracardiac parasympathetic stimulations) and during acetylcholine (ACh) infusion. Transmural repolarization gradients did not increase during intracardiac parasympathetic stimulation and during ACh infusion compared to during control. During ACh infusion, at rial tachyarrhythmia (AT) was initiated with a single premature stimulus and was associated with a focal pattern of activation (84 %). Importantly, AT initiation during intracardiac parasympathetic stimulations was also associated with the focal pattern of activity (36 %) without conduction block when repolarization gradients were small. During … More intracardiac parasympathetic stimulations, however, when repolarization gradients were large, patterns of conduction block and incomplete macroreentry were often observed (64 %). During pituitary adenylate activating polypeptide injection, repolarization gradients were small across the atrial surface and transmirally and a single premature stimulus initiated AT which was associated with a focal pattern of activation (100 %) without conduction block. These results suggest that the complicated tissue structure of atrial tissue has an important role for initiating focal pattern of AT. We examined the spatial variation in ionic current density us ing E-4031, the rapidly activating component of delayed rectifier potassium current blocker, and Zatebradine, hyperpolarization activated-current blocker. E-4031 increased action potential duration (APD) greater in the right atrial free wall than in the pulmonary vein area of left atrium. In contrast, Zatebradine equally increased APD between them. These results suggest the regional variation in atrial ionic currents. Less
在离体犬心房动脉灌注时,采用高分辨率光学成像技术测量心外膜和心内膜表面右侧无心室壁的动作电位,观察到跨壁复极化梯度。在对照条件下,在右肺静脉-心房交界处的脂肪垫电刺激(即心内副交感神经刺激)和乙酰胆碱(ACh)输注期间进行这些检查。与对照组相比,在心内副交感神经刺激和乙酰胆碱输注期间,跨壁复极化梯度没有增加。在乙酰氨基乙酰ACh输注过程中,单次过早刺激引发急性心动过速(at),并伴有局灶性激活模式(84%)。重要的是,当复极化梯度较小时,心内副交感神经刺激时AT的启动也与无传导阻滞的局灶性活动模式(36%)相关。然而,在更多的心内副交感神经刺激时,当复极化梯度较大时,经常观察到传导阻滞和不完全大再入模式(64%)。在垂体腺苷酸激活多肽注射期间,心房表面和心房传导的复极化梯度很小,单次过早刺激引发AT,与无传导阻滞的局灶型激活(100%)相关。这些结果表明,心房组织复杂的组织结构对心房心房颤动局灶型的发生具有重要作用。我们用延迟整流钾电流阻滞剂的快速激活成分E-4031和超极化激活电流阻滞剂Zatebradine检测了离子电流密度的空间变化。E-4031对右心房游离壁动作电位持续时间的影响大于左心房肺静脉区。相比之下,Zatebradine增加了APD。这些结果提示心房离子电流存在区域差异。少
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
弘瀬 雅教: "Cellular mechanisms of vagally-mediated atrial tachyarrhythmia in isolated arterially perfused canine right atria"Journal of Cardiovascular Electrophysiology. 13巻9号. 918-926 (2002)
Masanori Hirose:“离体动脉灌注犬右心房迷走神经介导的房性快速性心律失常的细胞机制”《心血管电生理学杂志》,第 13 卷,第 9 期。918-926 (2002)
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Masamichi Hirose: "Partial Vagal Denervation Increases Vulnerability to Vagally Induced Atrial Fibrillation"J Cardiovas Electrophysiol. Vol.13 No.12. 1272-1279 (2002)
Masamichi Hirose:“部分迷走神经去神经会增加迷走神经诱发心房颤动的脆弱性”J Cardiovas Electrophysicalol。
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HIROSE Masamichi其他文献
HIROSE Masamichi的其他文献
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{{ truncateString('HIROSE Masamichi', 18)}}的其他基金
Roles of TRPC channel activation in the induction of ventricular tachycardias
TRPC 通道激活在诱发室性心动过速中的作用
- 批准号:
21590276 - 财政年份:2009
- 资助金额:
$ 2.62万 - 项目类别:
Grant-in-Aid for Scientific Research (C)