Statistical analysis of vertebral degeneration by using MR and multi-modalities

本研究的目的是提高多功能磁共振方法对脊柱疾病的诊断准确性，本研究使用的设备是Gyroscan Intera (1.5T, philips), Magnetom （1.5T, Siemens）和MR Mics （Jonan electron）用于磁共振显微镜。虽然MR显微镜将用于分析手术获得的样品，但在本研究期间没有获得合适的样品。在临床MRI上调整测量顺序。由于椎体含有大量脂肪，因此检查了MRS的脂肪抑制序列。由于患者的运动，使用脂肪抑制MRS无法获得氨基酸的信号。检测脂肪和水信号。在扩散图像中，考察了最佳B值。当B值大于500时，很难获得足够的信号。将这些应用于患者并对脊柱疾病进行分析。在MRS中，个体差异太大，无法分析统计学意义，但假设在骨质疏松症和转移性脊柱肿瘤中脂肪信号降低。扩散加权图像分析存在个体差异大的困难。由于获得的数据表明个体差异太大，因此似乎有必要建立个体差异的补偿方法

The purpose of this study is to improve the diagnosis accuracy by the application of the multifunctional MR method for the spinal diseasethe utilized equipments in this study were Gyroscan Intera (1.5T, Phillips), Magnetom (1.5T, Siemens) and MR Mics (Jonan electron) for MR Microscopy. Though the MR Microscopy would be used for the analysis of the sample got by operations, the appropriate sample was not obtained during this study period. The measurement sequence was adjusted on the clinical MRI. The fat suppression sequence for MRS was examined because the vertebral bodies contain a lot of fat. The signal of the amino acid by using the fat suppressed MRS was not obtained due to the patient movement. Fat and water signals were examined. In the diffusion image, the optimum B value was examined. It was difficult to obtain the sufficient signal when the B value was over 500. These were applied to the patient and the spinal disease was analyzed. In MRS, the individual difference was too big to analyze the statistical significance but it supposed that fat signal was lowered in osteoporosis and metastatic spinal tumors. There were difficulties that the individual difference was big in diffusion weighted image analysis. It seems to be necessary to establish a compensation method for individual difference because the obtained data demonstrated that individual difference it too big