Basic research of high-voltage X-ray CT converging radiotherapy

高压X射线CT会聚放疗基础研究

• 批准号: 13670964
• 负责人: KUNIEDA Etsuo
• 金额: $ 1.86万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670964/
• 关键词: Solitary lung tumor; Radiation therapy; Phantom; Stereotactic radiotherapy; Beam energy

Helped by the grant, we have completed a human chest phantom, which is based on a ellipsoid-shaped numerical phantom designed by M.Crysty. The phantom resembles a simplified model of human male chest and includes lung parenchyma in which a spherical tumor (GTV) of 2 cm diameter is included.A narrow beam of X-ray collimated to 3cm in diameter, was used to irradiate the phantom. A Monte-Carlo simulation was performed with EGS4 code and the result was analyzed. Lower energy X-ray irradiation indicated good flatness both in the direction of the beam incidence and perpendicular to it. On the other hand, due to the inhomogeneous density in the phantom chest,In 2002, we modified a helical CT scanner for diagnostic purpose. The CT device had been installed for experimental purposes at our department for the aim of a corporative work of the vender. Actual basic dosimetories were performed using micro-chamber and a diamond detector. Film measurements etc.were also performed. Respiration movements were also simulated and animal studies were carried out. Next step project that includes computer simulations and dose calculations, are now on-going study.

在该基金的帮助下，我们完成了一个人体胸部模型，它是基于M.Crysty设计的椭圆形数值模型。该体模类似于人体男性胸部的简化模型，包括肺实质，其中包含直径为2 cm的球形肿瘤（GTV），使用准直至直径为3 cm的窄束X射线照射该体模。采用EGS4程序对该模型进行了蒙特-卡罗模拟，并对模拟结果进行了分析。低能量X线照射显示出良好的平坦度，无论是在射束入射方向和垂直于它。另一方面，由于在模胸密度不均匀，在2002年，我们修改了螺旋CT扫描仪的诊断目的。CT设备已安装在我们部门的实验目的，为供应商的合作工作的目的。实际的基本剂量学是使用微室和金刚石探测器进行的。还进行了膜测量等。还模拟了呼吸运动，并进行了动物研究。下一步项目包括计算机模拟和剂量计算，目前正在进行研究。

项目成果

Etsuo Kunieda, Osamu Kawaguchi et al.: "Intra-arterial CT-Angiography for Cerebral Arteriovenous Malformation Initial Experiences for Treatment Planning of Radiosurgery"International Journal of Radiation Oncology, Biology and Physics. 54.4. 120-132 (2002)

Etsuo Kunieda、Osamu Kawaguchi 等人：“脑动静脉畸形的动脉内 CT 血管造影对于放射外科治疗计划的初步经验”国际放射肿瘤学、生物学和物理学杂志。