The effect of hypocpnia and anesthetics on cerebral damage in a rat model of chronic cerebral hypoperfusion

低氧和麻醉对慢性脑低灌注大鼠模型脑损伤的影响

• 批准号: 13671621
• 负责人: TAKAHIRA Takahira
• 金额: $ 1.86万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671621/
• 关键词: Chronic cerebral hypoperfusion; White matter lesion; Hypocapnia; Caudoputamen; Ketamine; NMDA受容体拮抗薬; 慢性脳低灌流ラット; caudoputamen; ハロタン; イソフルラン; 脳慢性低灌流ラット; 術後譫妄

White matter lesions are characteristic in a rat model of chronic cerebral hypoperfusion, which is a good model for patients with cerebrovascular diseases. Hypocapnia, induced by hyperventilation, caused specific further neuronal damage in the caudoputamen, which was ameliorated by ketamine pre-administration. These results suggest that hypocapnia during anesthesia may cause tissue damage in the caudoputamen, which may be responsible for long-lasting postoperative delirium and/or memory disturbances in patients with stroke and/or cerebrovascular dementia, and ketamine seems to be useful for preventing the damage.

脑白质损害是慢性脑低灌注大鼠模型的特点，是脑血管疾病患者的良好模型。过度换气所致的低碳酸血症可进一步引起尾壳核神经元的进一步损伤，而预先给予氯胺酮可改善这种损伤。这些结果表明，麻醉期间的低碳酸血症可能会导致尾壳核的组织损伤，这可能是中风和/或脑血管性痴呆患者术后长期神志不清和/或记忆障碍的原因，而氯胺酮似乎对预防这种损伤是有效的。

项目成果

Uka Uchiyama: "Role of mitochondrial KATP channels and protein kinase C in ischaemic preconditioning"Chin Exp Pharmacol Physiol. 30. 426-436 (2003)

Uka Uchiyama：“线粒体 KATP 通道和蛋白激酶 C 在缺血预处理中的作用”Chin Exp Pharmacol Physiol。

Etusko Miyamoto: "Caudoputamen is damaged by hypocapnia during mechanical ventilation in a rat model of chronic cerebral hypoperfusion"Stroke. 32. 2920-2925 (2001)

Etusko Miyamoto：“在慢性脑灌注不足的大鼠模型中，机械通气期间，尾壳核因低碳酸血症而受损”。

Takefumi Inada: "Propofol depressed neutrophil hydrogen peroxide production more than midazolam, whereas adhesion molecule expression was minimally affected by both anesthetics in rats with abdominal sepsis"Anesthesia & Analqesia. 92. 437-441 (2001)

Takefum​​i Inada：“在腹部脓毒症大鼠中，异丙酚比咪达唑仑更能抑制中性粒细胞过氧化氢的产生，而两种麻醉剂对粘附分子表达的影响最小”

Etsuko Miyamoto: "Caudoputamen is damaged by hypocapnia during mechanical ventilation in a rat model of chronic cerebral hypoperfusion"Stroke. 32. 2920-2925 (2001)

Etsuko Miyamoto：“在慢性脑灌注不足的大鼠模型中，机械通气期间，尾壳核因低碳酸血症而受损”。

Etsuko Miyamoto: "Ketamine attenuates hypoxia-induced neuronal damage in the caudoputamen in a rat model of chronic cerebral hypoperfusion"Neuroscience Letters. 354. 26-29 (2004)

Etsuko Miyamoto：“氯胺酮可减轻慢性脑灌注不足大鼠模型中缺氧引起的尾壳神经元损伤”《神经科学快报》。