权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Chronobiological Study of Nocturia

夜尿的时间生物学研究

基本信息

批准号：
13671661
负责人：
YASUKUNI Yoshimura
金额：
$ 1.41万
依托单位：
Fukushima Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671661/
关键词：
Rat Freauency Volume Chart Nocturia Circadian Rhythm sleep サーカデイアンリズム

项目摘要

Micturition volume (V) and frequency (F) characteristics of rats were evaluated for 24 hours continuously using special metabolic cage study. The Frequency/Volume chart of rats clearly demonstrated the circadian rhythmicity of micturition pattern. Rats void frequently with small volume during dark, cycle when they are active and vice versa during light cycle when they are sleeping.Since sleeping drugs was capable of increasing rats' bladder capacity only when rats were sleeping, it is assumed that bladder capacity may be coupled with the depth of sleep.Finally, the study was designed to investigate experimentally whether FVC can predict BOO(bladder outlet obstruction) in rats. It is concluded that FVC can predict BOO with accuracy rate of 82% and therefore, invasive urodynamics can be spared in mildly obstructed rat with no residual.

采用代谢笼法连续24 h测定大鼠排尿量（V）和排尿频率（F）。大鼠排尿频率/容量图显示了排尿的昼夜节律性。大鼠睡眠时，黑暗时排尿频繁，排尿量小，活动时排尿频繁，光照时排尿频繁。由于安眠药仅在大鼠睡眠时才能增加大鼠膀胱容量，因此推测膀胱容量可能与睡眠深度相关。最后，本研究旨在通过实验研究FVC能否预测大鼠膀胱出口梗阻（BOO）。FVC预测BOO的准确率为82%，因此，轻度梗阻无残留的大鼠可避免有创性尿动力学检查。