Clinical Application of Auditory Steady-State Response evoked by multiple simultaneous amplitude-modulated stimuli (amplitude-modulation following response : AMFR) for Assessment of hearing in infants and young children

多重同时调幅刺激引起的听觉稳态响应（调幅响应：AMFR）在婴幼儿听力评估中的临床应用

• 批准号: 13671765
• 负责人: WATANABE Tomoo
• 金额: $ 1.98万
• 依托单位: Yamagata-uniersity
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671765/
• 关键词: steady-state response; amplitude-modulation following response; multiple amplitude-modulated tones; 他覚的聴力検査装置; 他覚的聴力検査

In recent years newborn hearing screening has been widely implemented using automated ABR screener and EOAE test unit. However, hearing threshold prediction and follow-up evaluation using traditional ABR technique cannot provide sufficient information in a frequency-specific manner. Thus, it is necessary to develop new tests to obtain detailed information from specific cochlear regions. Our study is indicated about new detection algorithm to use multiple simultaneous amplitude-modulated stimuli and separate analysis for each MF with phase coherence. The responses for each MF are separated with software-triggering from the averaged waveforms to obtain using simultaneously multiple amplitude-modulated tones, from which the phase coherence value is calculated for each MF. Test reliability of SSR using simultaneously multiple amplitude-modulated stimuli (Four-CF combined stimulus in MFs around 40 HZ) with our detection algorithm was evaluated among normal-hearing adults and comparison with resulting in mono AM tone was performed. In addition examples of puretone audiograms and thresholds estimated from SSR using simultaneously multiple ampliude-modulated stimuli were demonstrated in adult subjects with hearing impairment. The new algorithm for response detection of SSR using simultaneously multiple amplitude-modulated stimuli at the optimal modulation rates is expected in clinical use for assessment of hearing in infants and young children.

近年来，使用自动化ABR筛查仪和EOAE测试装置广泛实施新生儿听力筛查。然而，使用传统的ABR技术进行听阈预测和随访评估不能以频率特异性的方式提供足够的信息。因此，有必要开发新的测试，以获得来自特定耳蜗区域的详细信息。我们的研究表明，新的检测算法，使用多个同时调幅刺激和单独的分析，为每个MF与相位相干。每个MF的响应通过软件触发从平均波形中分离出来，以同时使用多个调幅音调获得，从中计算每个MF的相位相干值。在听力正常的成年人中评估了同时使用多个调幅刺激（40 Hz左右的MF中的四CF组合刺激）与我们的检测算法的SSR的测试可靠性，并与产生的单AM音进行了比较。此外，纯音听力图和阈值估计SSR同时使用多个调制的刺激的例子被证明在成年受试者的听力障碍。在最佳调制率下同时使用多个调幅刺激进行SSR响应检测的新算法有望在临床上用于评估婴幼儿的听力。

项目成果

鈴木 豊, 大竹祐輔, 布施健生, 伊藤智史, 伊藤 吏, 横田雅司, 青柳 優: "複合振幅変調音刺激によるAMFRの高調波歪み解析の試み"Audiology Japan. 44. 385-386 (2001)

Yutaka Suzuki、Yusuke Otake、Takeo Fuse、Satoshi Ito、Tsutomu Ito、Masashi Yokota、Yu Aoyagi：“尝试使用复杂的调幅声音刺激来分析 AMFR 的谐波失真”Audiology Japan。