BASIC AND CLINICAL RESEARCH OF MONITOR FOR NEUROPROTECTION

自动视野计已被用于监测视神经疾病的视觉功能。估计青光眼患者的视野变化需要一年多的时间。倍频视野计(FDP)已被开发用于青光眼筛查，可以检测青光眼视野缺陷。FDP对青光眼的敏感性为98%，特异性为90%。我们研究了FDP作为青光眼监测器的作用。青光眼患者和常规自动视野检查训练有素的患者对FDP有学习效果。FDP的第一个结果应删除以供估计(Fujimoto等人，Am J Ophthalmol2002)。随后使用FDP进行的两次测量由于疲劳导致敏感度降低(Zhang等人，Am J Ophthalmol2003)。对侧眼严重受损的眼睛表现出相对的过敏性(Fujimoto等人，Am J Ophthalmol2003)。FDP的短期和长期波动几乎与传统的自动视野检查相同(Minowa等人，Chiba Med J 2003)。我们还没有获得用于内科和外科治疗的有用数据。

Automated perimetry has been used for monitoring visual function in optic nerve diseases. It takes over one year to estimate the change of visual field in glaucoma patients. Frequency doubling perimetry (FDP) has been developed for glaucoma screener and could detect glaucomatous visual field defects. FDP had 98% sensitivity and 90% specificity for glaucoma. We studied FDP as a monitor for glaucoma. The patients with glaucoma and well-trained by conventional automated perimetry showed a learning effect for FDP. The first results of FDP should be deleted for estimation (Fujimoto et al, Am J Ophthalmol 2002). Two consequent measurements with FDP produced decreased sensitivity due to a fatigue (Zhang et al, Am J Ophthalmol 2003). Eye with severely damaged contralateral eye showed relative hypersensitivity (Fujimoto et al, Am J Ophthalmol 2003). FDP had almost the same short- and long-term fluctuation as conventional automated perimetry (Minowa et al, Chiba Med J 2003). We have not obtain useful data for medical and surgical therapy.