Treatment of Diabetic Retionpathy by Inhibition of Adhesion Molecules

在糖尿病性视网膜病变中，白细胞积聚通过白细胞-内皮细胞相互作用的刺激而升高。积聚的白细胞损伤血管内皮细胞并导致血-视网膜屏障破坏。白细胞与内皮细胞的相互作用受粘附分子如P-选择素或ICAM-1的调节。抗凝血酶III和组胺H1受体拮抗剂抑制粘附分子的表达和白细胞-内皮细胞相互作用。这些结果表明，这些药物可能对糖尿病视网膜病变具有相同的作用。这种方法是有价值的，因为这些相互作用刺激白细胞-内皮细胞的相互作用，除了血小板活化。此外，散射激光光凝后的视网膜炎症反应进行了评估。散射激光光凝是治疗糖尿病视网膜病变的主要方法，炎症反应是其严重并发症之一。白细胞-内皮细胞相互作用在该模型中起重要作用，抑制白细胞-内皮细胞相互作用可能有助于治疗糖尿病视网膜病变激光治疗后的炎症反应

In diabetic retinopathy, leukocyte accumulation is elevated by the stimulation of leukocyte-endothelial cell interactions. The accumulated leukocytes injure the vascular endothelial cells and leads to the blood-retinal barrier breakdown. The leukocyte-endothelial cell interactions are regulated by adhesion molecules, such as P-selection or ICAM (intracellular adhesion molecule)-1. Antithrombin III and histamine H1 receptor antagonist inhibited the expression of adhesion molecules and leukocyte-endothelial interactions. These results suggest that these drugs may have same effects in diabetic retinopathyPlatelet-endothelial cell interactions in the retinal microcirculation are quantitatively evaluated. This method is valuable because these interactions stimulate leukocyte-endothelial cell interactions in addition to platelet activationMoreover, the inflammatory response after scatter laser photocoagulation in retina was evaluated. The scatter laser photocoagulation is a major treatment for diabetic retinopathy and inflammatory reactions are one of the severe complications. Leukocyte-endothelial interactions play an important role in this model and it may be useful to inhibit the interactions to treat the inflammation after laser treatment in diabetic retinopathy