Study on bone regeneration using an absorbable osteoconductive material with a jungle gym structure

使用攀登架结构可吸收骨传导材料进行骨再生的研究

• 批准号: 13672096
• 负责人: MANO Takamitsu
• 金额: $ 2.24万
• 依托单位: Yamaguchi University (2002-2003)Okayama University (2001)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672096/
• 关键词: poly lactic acid; osteoconductive material; absorbable; bone regeneration

We could make a poly lactic acid (PLLA) sheet having a pore by dissolving with a solvent. Furthermore, we could adhere hydroxyapatite (HA) powder on the surface of the PLLA by a solventA bicortical bone defect in the tibia of the rat was made. The bone defect was covered with PLLA sheet or PLLA sheet adhering HA powder. The rats were killed at 1,2 and 4 weeks after surgery. The tibia was excised with surrounding tissue. Sections were prepared and were stained with hematoxylin-eosin for light microscopy. Consequently, we found that the defect was restored to nealy original condition. In the case of PLLA sheet adhering HA powder, the result was the same of PLLA sheet. A few inflammatory reaction was observed during the experimental periods. PLLA was not resorbed at four weeks after implantationIn conclusion, we found that PLLA sheet functioned effectively as a GBR membrane

我们可以通过用溶剂溶解来制备具有孔的聚乳酸（PLLA）片材。此外，我们还可以通过溶剂将羟基磷灰石（HA）粉末粘附在PLLA表面，制作大鼠胫骨双皮质骨缺损。用PLLA片或粘附HA粉末的PLLA片覆盖骨缺损。手术后1，2和4周处死大鼠。将胫骨连同周围组织一起切除。制备切片并用苏木精-伊红染色以用于光学显微镜检查。结果，我们发现缺陷几乎恢复到原来的状态。在PLLA片材附着有HA粉末的情况下，结果与PLLA片材相同。实验期间观察到一些炎症反应。植入后 4 周，PLLA 未再吸收。结论是，我们发现 PLLA 片可以有效地充当 GBR 膜