PET・SPECTにおける機能・放射能分布測定を行う輪郭抽出・解析ツールの開発

开发轮廓提取和分析工具，用于测量 PET 和 SPECT 中的功能和放射性分布

• 批准号: 13770484
• 负责人: 久保 直樹
• 金额: $ 0.83万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13770484/
• 关键词: 輪郭抽出; 心電図同期PET; ファントム; 心電図同期SPECT; 統計的1次モーメント法; ガウス関数近似法

心電図同期PET(ポジトロン断層)は心機能と代謝を同時に調べることができる.また心筋厚は,左心室機能や心疾患の判定に対して重要な情報を与える.今回,心電図同期心筋PETを用いて心筋厚を自動的に測定するプログラムを開発した.使用言語は,科学技術データ解析用パッケージInteractive Data Language (IDL)であった.アルゴリズムは,まずアンシャープマスキングでボケを除去した.次に放射能が高集積の部位を1,その他を0とする2値画像に変換した.そして,2値画像の基本的処理のひとつである距離変換を行った.距離変換後の画像は,形はオリジナルの2値画像と同じで,画素の値は0-画素への最短距離を示すものとなった.この距離から心筋厚を求めた.このようにして求められた画像は,形が心筋そのもので,画素の値が心筋厚を示しているものとなった.これを極座標表示することで各領域の心筋厚を計測した.このプログラムをファントムデータで評価した.使用装置はPET装置シーメンスEXACTであった.心筋動態ファントムを作製し,これにF-18を封入して心電図同期PETを撮像した.収集はファントムからの信号で同期し,16分割とした.結果は,測定された収縮期心尖部厚は2.3cmであり,真の値から0.3cmほど過小評価した.測定された収縮期心基部厚は0.03-0.39cmであり,真の値から0.03-0.39cmほど過小評価した.実際の心筋厚が1.0cm以上の領域に限ると,測定された心筋厚と真の値は非常に良い相関を示した(y=0.01+0.93x, r=0.89, S.E.E.=0.18cm).以上のように,PETの断層像から自動的に心筋厚を計算できた.実験結果からは,実際の心筋厚が1.0cm以上の領域においてPETは精度良く心筋厚を測定できるといえた.

At the same time, the PET will be able to do the same thing at the same time. If you have a thick heart, the left ventricle machine can determine the importance of heart disease. This time, the heart PET uses the automatic test of the thickness of the heart to make sure that the heart is in full swing. In terms of language, science and technology, Interactive Data Language (IDL) is used in the analysis of science and technology. I'm sorry, I'm sorry. The second part of the high concentration of radioactive energy is 1, the portrait of him is 0 and 2, and the portrait is very high. The basic principle of the portrait is that it is far away from the line. From the back of the portrait, the shape of the portrait is the same as that of the portrait, and the pixel is the shortest distance away from the portrait. Please be far away from me and ask for a thick heart. He asked for a portrait, the shape of the heart, the thickness of the heart, the thickness of the heart. The seat means that the heart is thicker and thicker in all fields. I don't know. I don't know what to do. Use the device "PET device", "EXACT device" and "device". In the mental state of mind, you will be able to make a picture of yourself, and you will be able to seal it in your heart. The signal is in the same period, which is divided into 16 segments. The results showed that the apical thickness of the heart was measured, and the apical thickness of the heart was measured. The results showed that the apical thickness of the heart was measured, and the apical thickness of the heart was measured. The results showed that the apical thickness of the heart was measured, and the apical thickness of the heart was measured. The results showed that the apical thickness of the heart was measured during the 2.3cm period. The thickness of the base of the heart is measured to be 0. 03-0.39cm, and the true thickness is 0. 03-0.39cm. The thickness of the heart is higher than 1.0cm, and the measurement of the thickness of the heart is very good. (y, 0.01, 0.93x, r, 0.89, S.E.E.=0.18cm). As for the above information, the PET is like the automatic calculation of heart thickness. The results show that the thickness of the heart is higher than 1.0cm, the accuracy of the PET is good, and the thickness of the heart is measured.

项目成果

Kubo N: "Validation of left ventricular function from gated SPECT using a scintillator-photodiode camera : a dynamic myocardial phantom study"Nuclear Medicine Communications. 23. 639-643 (2002)

Kubo N：“使用闪烁体光电二极管相机通过门控 SPECT 验证左心室功能：动态心肌模型研究”核医学通讯。

Kubo N: "Validation of left ventricular function from gated SPECT using a scintillator-photodiode camera : a dynamic myocardial phantom study"Nuclear Medicine Communications. (In press).

Kubo N：“使用闪烁体光电二极管相机通过门控 SPECT 验证左心室功能：动态心肌模型研究”核医学通讯。