Release control of cyclodextrin intercalated hydrotalcite

环糊精插层水滑石的释放控制

• 批准号: 14550804
• 负责人: TSUHAKO Mitsutomo
• 金额: $ 2.24万
• 依托单位: Kobe Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14550804/
• 关键词: Cyclodextrin; Hydrotalcite; Release Profile; シクロデストリン

Intercalation of SBE7-β-cyclodextrin into hydrotalcite was examined aiming for DDS host. By changing the concentration of SBE7-β-cyclodextrin aqueous solution, uniform intercalation compounds with different amount of intercalated SBE7-β-cyclodextrin were obtained.Two methods were used for the introduction of drug in the cyclodextrin cavity, that is, (1)inclusion of drug in cyclodextrin in aqueous solution and then the intercalation of drug included cyclodextrin, (2)inclusion of drug directly into SBE7-β-cyclodextrin intercalated hydrotalcite. At that time the amount of included drug could be regulated by changing the concentration of SBE7-β-cyclodextrin aqueous solution and solvents.Release profiles into H_2O and JP XIII 2^<nd> fluid were examined for the obtained compounds. Release profile depended on the uptake amount of cyclodextrin. Especially, delayed release profile was obtained for SBE7-β-cyclodextrin intercalated hydrotalcite with the uptake amount of 4 mmol/g of hydrotalcite.

研究了SBE7-β-环糊精在水滑石中的插层行为。通过改变SBE7-β-环糊精水溶液的浓度，得到了不同插层量的均一的SBE7-β-环糊精插层化合物。采用两种方法将药物引入环糊精空腔，即(1)将药物包合到水溶液中的环糊精中，然后将药物插层到SBE7-β-环糊精水滑石中。通过改变SBE7-β-环糊精水溶液和溶剂的浓度来调节药物的包封量。考察了化合物在水和JP XIII2和JP XIII2中的释放曲线。释药曲线取决于环糊精的摄取量。其中，SBE7-β-环糊精插层水滑石的缓释曲线为4 mmo1/g水滑石。

项目成果

Hirokazu Nakayama: "Synthesis of A New Template Free Microporous Silicoaluminophosphate (Si_2AIP_3O_<13>) and its Characterization by Solid-State NMR"Microporous Mesoporous Mater.. 51・1. 7-15 (2002)

Hirokazu Nakayama：“新型无模板微孔硅铝磷酸盐（Si_2AIP_3O_<13>）的合成及其固态NMR表征”微孔介孔材料.. 51・1（2002）

Synthesis and aldehyde absorption properties of aspartate-octacalcium phosphate inclusion compound

• DOI: 10.1016/j.jpcs.2003.10.030
• 发表时间: 2004-02-01
• 期刊: JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
• 影响因子: 4
• 作者: Aoki, S;Nakahira, A;Suganuma, K
• 通讯作者: Suganuma, K

Phosphorylation of Maltotriose by Inorganic cyclo-Triphosphate

无机环三磷酸酯对麦芽三糖的磷酸化

• 发表时间: 2003
• 期刊: Phosphorus Res.Bull. 16
• 作者: Hirokazu Nakayama;et al.;Hirokazu Nakayama;Hirokazu Nakayama;Hirokazu Nakayama;Hirokazu Nakayama
• 通讯作者: Hirokazu Nakayama

Preparation of 1-Hydroxyethylidene-1, 1-diphosphonic acid-Layered Double Hydroxyide Nanocomposite and its Physicochemical Properties

1-羟基亚乙基-1,1-二膦酸层状双羟基纳米复合材料的制备及其理化性能

• 发表时间: 2003
• 期刊: J.Pharm.Sci. 92
• 作者: Hirokazu Nakayama;et al.;Hirokazu Nakayama;Hirokazu Nakayama;Hirokazu Nakayama
• 通讯作者: Hirokazu Nakayama

Preparation of 1-Hydroxyethylidene-1,1-diphosphonic acid-Layered Double Hydroxyide Nanocomposite and its Physicochemical Properties

1-羟基亚乙基-1,1-二膦酸层状双羟基纳米复合材料的制备及其理化性能

• 发表时间: 2003
• 期刊: J.Pharm.Sci. 92
• 作者: Hirokazu Nakayama;et al.
• 通讯作者: et al.