Release control of cyclodextrin intercalated hydrotalcite

研究了SBE7-β-环糊精在水滑石中的插层作用。通过改变SBE7-β-环糊精水溶液的浓度，得到了不同插层量的均匀插层化合物。在环糊精腔内引入药物的方法有两种，即(1)将药物包埋在水溶液中的环糊精中，再将含环糊精的药物插入；(2)将药物直接包埋在SBE7-β-环糊精插层水滑石中。此时可以通过改变SBE7-β-环糊精水溶液和溶剂的浓度来调节药物的掺入量。对所得化合物在H_2O、JP XIII 2^<和>流体中的释放曲线进行了检测。释放曲线与环糊精的摄取量有关。其中，SBE7-β-环糊精插层水滑石在吸收量为4 mmol/g时获得了较好的缓释效果。

Intercalation of SBE7-β-cyclodextrin into hydrotalcite was examined aiming for DDS host. By changing the concentration of SBE7-β-cyclodextrin aqueous solution, uniform intercalation compounds with different amount of intercalated SBE7-β-cyclodextrin were obtained.Two methods were used for the introduction of drug in the cyclodextrin cavity, that is, (1)inclusion of drug in cyclodextrin in aqueous solution and then the intercalation of drug included cyclodextrin, (2)inclusion of drug directly into SBE7-β-cyclodextrin intercalated hydrotalcite. At that time the amount of included drug could be regulated by changing the concentration of SBE7-β-cyclodextrin aqueous solution and solvents.Release profiles into H_2O and JP XIII 2^<nd> fluid were examined for the obtained compounds. Release profile depended on the uptake amount of cyclodextrin. Especially, delayed release profile was obtained for SBE7-β-cyclodextrin intercalated hydrotalcite with the uptake amount of 4 mmol/g of hydrotalcite.