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拡散テンソル解析を用いた脳機能ネットワークにおける神経線維描出の研究

利用扩散张量分析研究脑功能网络中的神经纤维描述

基本信息

批准号：
14770446
负责人：
森墾
金额：
$ 0.7万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

项目摘要

1.初年度では,まず拡散テンソルを使った神経線維描出の基本ソフトの開発を行った.予定では初年度から正常被検者の募集を行い,対象者全員の撮影を達成する計画であったが,神経線維描出のソフト開発に時間がかかることが分かり,これに専念するために研究計画に述べたデータの収集は次年度に持ち越して行うこととした.2.本年度は3次元コンピュータグラフィクスの手法を利用して,トラクトグラフィーによる脳の各部位における拡散異方性の視覚的評価法を開発し,学会および論文発表した.また,トラクトグラフィーを使った皮質脊髄路の簡易描出法としてone-ROI法とtwo-ROI法を比較検討も論文発表した.対象は健常ボランティア5名(平均34.8±3歳,総て男性)であり,左右合計10大脳半球について評価した.開発したトラクトグラフィーは汎用表示ソフトウェア(VOLUME-ONE)と拡張ソフトウェア(VizDT-II)による拡散係数最大方向の追跡表示である.任意断面上の任意形状関心領域(ROI)による開始点と標的領域の設定ができる.開始ROI内では一定密度の開始点から軌跡の計算が始まる.また,軌跡上の各点の拡散異方性に応じた色づけができ,最大追跡方向の信頼性が分かる.つまり,赤色は線状拡散,黄色は面状拡散で,白色は球状拡散を表す.異方性(FA値)や見かけの拡散係数(ADC値)による軌跡終端条件などの各種設定も出来る.今回の検討によりone-ROI法およびtwo-ROI法を使ったトラクトグラフィーで簡便に皮質脊髄路が描出されることが確認された,トラクトグラフィーは梗塞などの白質病変による臨床症状の説明や予後予測,脳腫瘍の浸潤評価やナビゲーションなどにすぐにでも応用できると期待される.

1. At the beginning of the year, during the first year of the year, we made a lot of efforts to make the god describe the basic information and start the operation. In the early part of the year, when it is scheduled that the normal recipients will be invited to raise funds in the beginning of the year, the whole staff of the audience will be able to draw a picture of the plan to start the program, and the god will draw a picture of the opening time of the program, the training schedule, the research plan, and the annual training program. 2. For the third time this year, we have used the method to make sure that all parts of the body are affected by the spread of sex, and learn to read the list of documents. To make sure that the spine is easy to trace, the one-ROI method, the two-ROI method, the table, the table. There were 5 healthy adults (an average of 34.8 ±3, male), with a total of 10 hemispheres. This is indicated by the tracking in the direction of the maximum number of scattered data in the direction of the maximum number of scattered data in the direction of the maximum number of scattered data, which is indicated by the direction in which the maximum number of scattered data (VOLUME-ONE) is expressed in the direction of the maximum number of scattered data. On any cross-section, the domain setting of the starting point of the arbitrary shape centroid field (ROI) is set. Start the calculation of a certain density in the ROI at the beginning of the calculation. On the top of the table, the points are scattered, the color is scattered, and the direction of the maximum tracking direction is divided. It is scattered in red, yellow, and white in spherical shape. The number of FA attributes (ADC) is different from the settings of the terminal conditions. This time, the one-ROI method and the two-ROI method were used to make sure that the back of the skin was marked, the symptoms of the white disease were confirmed, the symptoms of the bed were known, and the symptoms of the bed were known later.