ADP-ribosyl cyclase coupled with dopamine receptors : Application to Parkinson's disease

我们研究了环adp核糖（cADPR）作为纹状体皮层和NG108-15细胞受体下游的第二信使的作用。为了解决这个问题，我们在转染CD38的大鼠纹状体和NG108-15细胞的粗膜部分测量了adp -核糖基环化酶的活性。多巴胺（DA）刺激环化酶活性。过表达细胞的环化酶活性对神经元功能有不同的影响。以下两份报告是综述表（7-2）对cADPR功能的总结和CD38转染的研究报告（7-3）。

We examined the role of cyclic ADP-ribose (cADPR) as a second messenger downstream of receptors in the striatal cortex and NG108-15 cells. To address this question, ADP-ribosyl cyclase activity was measured in a crude membrane fraction of rat striatum and NG108-15 cells transfected with CD38. Dopamine (DA) stimulated the cyclase activity. The cyclase activity in overexpressed cells had various effects on neuronal function. The following two reports are the summary of the cADPR function written in a review form (7-2) and research report on CD38 transfection (7-3)