Study of the late effect on occurrence of thyroid and lung cancers of low dose irradiation from the atomic bomb tests in the Marshall Islands

马绍尔群岛原子弹试验低剂量辐照对甲状腺癌和肺癌发生的后期影响研究

• 批准号: 15406023
• 负责人: FUJIMORI Keisei
• 金额: $ 8.13万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15406023/
• 关键词: late effect of irradiation; Bravo test; thyroid cancer; lung cancer; breast cancer; Marshall Islands; DM; chronic thyroiditis; 放射性被爆晩期効果; 放射線被曝晩期効果; 低線量被曝; 放射線発癌; ビキニ事件; ヨード摂取量

We have done thyroid examinations (interviews on residency and smoking history, palpation, ultra-sono-tomography, blood sampling for thyroid function and auto-antibody ; AB : TGAb, TPOAb) for 1386 Marshalleses (mean age 50.9+/-12.34yo) from Feb 20 to Mar 22, 2006, at Majuro. The 386 people have belonged to the BRAVO cohort. The cohort was consisted of the Marshalleses born before BRAVO test on Mar 1,1954 at Bikini and had had our thyroid examination from 1993 to 1997 at Majuro and other atolls. It had had 3714. The 1055 of the cohort were under 5 yo at the BRAVO test. The 322 of the 1055 had thyroid re-examination at this time. We have found 4 strongly thyroid cancer suspected cases among the 322. The positive rate of Abs by CLEIA were around 20%. By palpation typical chronic thyroiditis was very rare, however, autoantibody positive ratio might not be low.We have reviewed the death certificates of the RMI. Till Dec 31, 2003 we have found 642 deaths of the BRAVO cohort. The mean death age was 63.9 yo. The 107 death causes were cancer. The most frequent was lung cancer and its number was 32 (23 men and 9 women). A comment of heavy smoker was seen in almost all men death certificates. The breast cancer death and the thyroid cancer death were 6 and two respectively. The cancers of digestive organs and uterus were popular. The other frequent death causes out of cancers were hepatic, respiratory, heart and renal failures, strokes, DM and sepsis.We have established the data base of the BRAVO cohort on death causes and thyroid cancers. The exact incidence of the thyroid cancer can be estimated on the data base and might be concluded the late effects of the irradiation among the Marshalleses from the dosimetry of each people.

2006年2月20日至3月22日，我们在马朱罗为1386名马绍尔人（平均年龄50.9+/-12.34岁）进行了甲状腺检查（居住地和吸烟史访谈、触诊、超声断层扫描、甲状腺功能和自身抗体的血液采样；AB：TGAb、TPOAb）。这 386 人属于 BRAVO 群体。该队列由 1954 年 3 月 1 日在比基尼岛进行 BRAVO 测试之前出生的马绍尔人组成，并于 1993 年至 1997 年在马朱罗和其他环礁进行了甲状腺检查。其中有 3714 名儿童。在 BRAVO 测试中，该队列中有 1055 名儿童不到 5 岁。 1055人中的322人此时进行了甲状腺复查。 322例中，发现4例疑似甲状腺癌，CLEIA抗体阳性率在20%左右。通过触诊，典型的慢性甲状腺炎非常罕见，但自身抗体阳性率可能不低。我们查阅了RMI的死亡证明。截至 2003 年 12 月 31 日，我们已发现 BRAVO 队列中有 642 例死亡。平均死亡年龄为 63.9 岁。 107人的死因是癌症。最常见的是肺癌，发病人数为 32 例（男性 23 例，女性 9 例）。几乎所有男性的死亡证明上都出现了重度吸烟者的评论。乳腺癌死亡人数为 6 人，甲状腺癌死亡人数为 2 人。消化器官和子宫癌很流行。其他常见的癌症死亡原因包括肝脏、呼吸系统、心脏和肾功能衰竭、中风、糖尿病和败血症。我们建立了 BRAVO 队列的死亡原因和甲状腺癌数据库。甲状腺癌的确切发病率可以根据数据库进行估计，并可以根据每个人的剂量测定得出马绍尔人辐射的后期影响。