Development of new medical gel materials using synthetic carbohydrate polymer

源自动物和人类的凝胶材料，例如明胶、胶原蛋白和纤维蛋白原，已广泛用于医疗应用，尽管这些材料包括病毒和过敏材料传染的可能性。我们最近发现一种具有特定结构的新型碳水化合物聚合物形成了一类新型凝胶材料。根据配方和制备方法，可以获得具有广泛变化的凝胶形成动力学的粘性液体、软凝胶和坚韧薄膜等材料。由于起始材料被归类为生物相容性和可生物降解性，这种新型凝胶具有许多潜在的医疗应用，例如止血剂、粘合剂和涂层剂。具有特定结构的碳水化合物聚合物可以由天然存在的糖或多糖微波分解的化合物合成。新型碳水化合物聚合物具有以下特点： 1）成本合理的医疗应用基础材料，2）化学和物理性能易于控制，3）生物相容性和可生物降解材料。碳水化合物聚合物与胶凝剂的反应立即形成凝胶材料，这与传统的凝胶制剂相比具有多种优点，包括使用非传染性材料和短的制备时间。凝胶材料是一种多功能的新型生物材料，有望用于各种医疗应用。

Gel-materials, such as gelatin, collagen, and fibrinogen, derived from animals and humans, have been used widely in medical applications, although the materials include the possibilities of the contagions of a virus and an allergic material. We recently discovered that a novel carbohydrate polymer having a specific structure formed a new class of gel-material. Depending on the formulation and preparation method, materials ranging from viscous liquids, soft gels, and tough films can be obtained with widely varying gel formation kinetics. Since the starting materials are classified as biocompatible and biodegradable, this new class of gels has many potential medical applications, such as hemostatic, adhesive, and coating agents. Carbohydrate polymers having a specific structure can be synthesized from naturally occurring sugars or compounds microwave-decomposed from polysaccharide. The novel carbohydrate polymers have characteristics as follows ; 1)basic materials for medical applications at a reasonable cost, 2)easy control of the chemical and physical properties, 3)biocompatible and biodegradable materials. The reaction of the carbohydrate polymer with a gelling agent immediately forms the gel-materials, which offers several advantages over conventional gel preparations, including the use of non-contagion materials and short preparation times. The gel-materials are a versatile new class of biomaterials that hold promise for a wide variety of medical applications.