Development and examination of safety of the drugs eluting thin layer covered stent

低侵袭性的IVR治疗，特别是血管内治疗，正在通过颈动脉支架、冠状动脉支架等方式被临床广泛推广。然而，这种治疗成败的关键是支架置入后再狭窄的预防。药物洗脱支架，如免疫抑制剂和抗癌药物，是集中在欧洲和美国制造商开发的，并报道了再狭窄率的降低。具有廉价和新机制的支架开发被认为是迫切需要的。通过优先研究，我们已经开发了自延伸镍钛合金支架，旨在获得胆道癌（仙台支架），并获得药物监管事务的认可。此外，它采用了Nakayama作为合作研究者（2004-2005）开发的覆膜技术，即接合，自延伸覆膜支架在试制中获得成功。我们正在研发的支架 关于我们 覆盖支架上的小孔，使支架管腔被自身内皮细胞覆盖，倾向于使滞留后的抗血栓治疗变得不必要，并倾向于防止支架管腔的再狭窄。在研究过程中，使用成年犬对覆膜支架进行改进，以检查其生物学有效性和安全性。可以开发新的覆膜支架，并且学会和报告公布了结果（Sato S，Nakayama Y，Ishibashi T. J Biomed Mater Res B Appl Biomater.2007）（T.Ishibashi，A.Sato，T.Matsuhashi，T.Yamada，K.Takase，S.Sato，Y.Nakayama自膨式镍钛合金微孔覆膜支架的新设计。实验研究）从动物实验数据中发现了一些应该改进的问题。例如，尽管在未覆盖时SENDAISTENT特有的弯曲和弯曲时的管腔保持良好，但在覆盖时管腔保持力恶化。作为该改进点，使人造血管的膜的厚度变薄，从而提高了弹性能力和延伸能力。虽然也有一个尚未解决的问题，但它已成为未来最大的课题。少

The IVR treatment of low invasiveness, especially endovascular treatment are spreading by clinical widely by the carotid artery stent, a coronary artery stent therapy,' etc. However, the key of the success or failure of this treatment is restenosis prevention after stent placement. Drugs elution stent, such as an immunosuppressant and an anti-cancer drug, is developed focusing on a European and American maker, and reduction of the rate of restenosis is reported. The stent development which had a cheap and new mechanism with it considered pressing need By precedence research, we already developed the self-extending Nitinol stent aimed at obtaining a biliary tract cancer (Sendai Stent), and also acquire drug-regulatory-affairs recognition. Moreover, it acted to the covering technology which Nakayama which was a co-investigator (2004-2005) developed as coaptation, and the self-extending covered stent is succeeded in the trial production. The stent which we are developing tends to make man … More y small holes in the covering stent, is making the stent lumen cover with self endothelial cells, tends to make the anti-thrombus therapy after detention unnecessary, and tends to prevent the restenosis of the stent lumen. Biological usefulness and safety were checked with improvement of the covered stent using adult dogs during the research. The new covering stent could be developed and the society and the report announced the result (Sato S, Nakayama Y, Ishibashi T. J Biomed Mater Res B Appl Biomater.2007) (T.Ishibashi, A.Sato, T.Matsuhashi, T.Yamada, K.Takase, S.Sato, Y.Nakayama A new design for a self-expanding, nitinol, microporous, covered stent. An experimental study ) The problem which some should improve from animal experiment data was found. For example, although incurvation peculiar to SENDAISTENT and the lumen retention at the time of meandering were good at the time of un-covering, lumen holding power deteriorated at the time of covering. Thickness of the velamen of an artificial blood vessel was made thin as this improving point, and elastic power and extended power have been improved. Although there is also a not yet solvable problem, it has been the biggest future subject. Less