Development and examination of safety of the drugs eluting thin layer covered stent

低侵袭性的IVR治疗，特别是血管内治疗正被临床广泛推广，如颈动脉支架、冠状动脉支架治疗等。然而，这种治疗成败的关键是防止支架置入后再狭窄。药物洗脱支架，如免疫抑制剂和抗癌药物，是针对一家欧美制造商开发的，据报道降低了再狭窄率。支架的开发具有廉价和新的机制，通过先期研究认为迫切需要，我们已经开发出了针对胆道癌的自伸型镍钛支架(仙台支架)，并获得了药品监管部门的认可。此外，它还借鉴了Nakayama(2004-2005)合作研究员开发的覆盖技术，并成功地试制了自伸展覆盖支架。我们正在开发的支架倾向于使人…覆膜支架上有较多的小孔，使支架管腔被自体内皮细胞覆盖，使滞留后的抗栓治疗变得不必要，并有防止支架管腔再狭窄的倾向。在研究期间，通过使用成年狗对被覆支架的改进来检查生物有效性和安全性。可以开发新的覆盖支架，协会和报告公布了结果(Sato S，Nakayama Y，Ishibashi T.J Bimed Mater res B Appl Biomater.2007)(T.Ishibashi，A.Sato，T.Matsuhashi，T.Yamada，K.T.Takase，S.Sato，Y.Nakayama)一种自膨胀的镍钛醇微孔覆盖支架的新设计。实验研究)从动物实验数据中找出需要改进的问题。例如，尽管在未覆盖时，森丹特有的弯曲和蜿蜒时的管腔保持良好，但在覆盖时，管腔保持力变差。作为这一改进点，将人工血管的膜厚度变薄，并提高了弹性力和伸长力。虽然也有一个尚未解决的问题，但它已经成为未来最大的课题。较少

The IVR treatment of low invasiveness, especially endovascular treatment are spreading by clinical widely by the carotid artery stent, a coronary artery stent therapy,' etc. However, the key of the success or failure of this treatment is restenosis prevention after stent placement. Drugs elution stent, such as an immunosuppressant and an anti-cancer drug, is developed focusing on a European and American maker, and reduction of the rate of restenosis is reported. The stent development which had a cheap and new mechanism with it considered pressing need By precedence research, we already developed the self-extending Nitinol stent aimed at obtaining a biliary tract cancer (Sendai Stent), and also acquire drug-regulatory-affairs recognition. Moreover, it acted to the covering technology which Nakayama which was a co-investigator (2004-2005) developed as coaptation, and the self-extending covered stent is succeeded in the trial production. The stent which we are developing tends to make man … More y small holes in the covering stent, is making the stent lumen cover with self endothelial cells, tends to make the anti-thrombus therapy after detention unnecessary, and tends to prevent the restenosis of the stent lumen. Biological usefulness and safety were checked with improvement of the covered stent using adult dogs during the research. The new covering stent could be developed and the society and the report announced the result (Sato S, Nakayama Y, Ishibashi T. J Biomed Mater Res B Appl Biomater.2007) (T.Ishibashi, A.Sato, T.Matsuhashi, T.Yamada, K.Takase, S.Sato, Y.Nakayama A new design for a self-expanding, nitinol, microporous, covered stent. An experimental study ) The problem which some should improve from animal experiment data was found. For example, although incurvation peculiar to SENDAISTENT and the lumen retention at the time of meandering were good at the time of un-covering, lumen holding power deteriorated at the time of covering. Thickness of the velamen of an artificial blood vessel was made thin as this improving point, and elastic power and extended power have been improved. Although there is also a not yet solvable problem, it has been the biggest future subject. Less