Logistic strategy for molecule-targeting therapy in brain tumors

确定脑肿瘤的治疗管理是基于个体患者的宿主因素和肿瘤因素。目前，PET等功能神经成像技术的发展表征了脑肿瘤的生理生化过程等体内肿瘤因素。为了检测脑膜瘤的体内转运系统和肿瘤增殖，采用^<18> f -氟脱氧葡萄糖（FDG）或^<18> f -氟硼苯丙氨酸进行动力学分析，并比较其对血管内皮生长因子（VEGF）和葡萄糖转运蛋白-1 （Glut-1）的免疫反应性。K1在脑膜瘤中高于胶质瘤，在非典型脑膜瘤中高于良性脑膜瘤。k3与脑膜瘤的增殖指数mb -1 LI相关。免疫组化结果显示，脑膜瘤对VEGF或Glut-1的反应低于胶质瘤，但非典型脑膜瘤比良性脑膜瘤染色更强烈。K1和k3的高值表明脑膜瘤的侵袭性增殖，在更典型的脑膜瘤中，高通透性和大表面积的协同相互作用产生了有利于葡萄糖代谢和肿瘤增殖的条件。FDG的摄取和分布是判断恶性程度和肿瘤范围的重要标志。肿瘤部分包括FDG摄取峰值部分是准确诊断恶性肿瘤的目标。高级别胶质瘤表现出不均匀的摄取模式，反映了由聚集的肿瘤细胞、坏死和肿瘤周围水肿组成的细胞组成的地形变化。在大多数良性肿瘤中，如脑膜瘤和中枢神经细胞瘤，非典型亚群有相对较高的FDG摄取。当不典型时，可以最大限度地缩小肿瘤肿块。本研究表明logistic支持因子促进肿瘤生长，包括肿瘤血管生成。临床应用较少侵入性的功能图像提供了多学科生物学特征，并根据肿瘤因素进行更适当的治疗，并可能延长脑肿瘤患者的高水平表现状态。少

Determination of therapeutic management of brain tumors is based on both host factors of individual patients and tumor factors. Current development in functional neuroimaging such as PET characterizes in vivo tumor factors including physiological and biochemical process of brain tumors.To test in vivo transport system and tumor proliferation of meningiomas, kinetic analysis using ^<18>F-fluorodeoxyglucose (FDG) or ^<18>F-fluoroboronophenylalanine-was obtained and compared with immunoreactivity to vascular endothelial growth factor (VEGF) and glucose transporter-1 (Glut-1). K1 was higher in meningiomas than in gliomas, and was higher in atypical than in benign meningiomas. k3 was correlated with a proliferating index, MIB-1 LI, in meningiomas. Immunohistochemically, meningiomas were less reactive to VEGF or Glut-1 than gliomas, but atypical meningiomas stained more intensely than benign meningiomas. High values for K1 and k3 indicate the aggressive proliferation of meningiomas, and in a … More typical meningiomas, the synergistic interaction of the high permeability and the large surface area yielded conditions conducive to glucose metabolism and tumor proliferation.The uptake and distribution of FDG is important landmark for malignancy and tumor extent. The tumor portion including a peak FDG uptake portion is a target for accurate diagnosis of malignancy. High-grade gliomas show heterogeneous uptake patterns, reflecting a topographic variation of cellular composition consisting of aggregated tumor cells, necrosis, and peritumoral edema. Among mostly benign tumors such as meningioma and central neurocytoma, atypical subsets have a relatively high uptake of FDG. The maximum reduction of tumor mass may be applied, when atypical.The present study indicates that logistic support factors enhance tumor growth including tumor angiogenesis. Clinical use of functional image less invasively provides multidisciplinary biologic characteristics and leads to more appropriate treatment based on the tumor factors, and may result in prolonging high levels of performance status in brain tumors. Less