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Brain mechanism on the binaural hearing and auditory-visual interaction assessed by the auditory evoked magnetic fields as well as conventional psychophysical methods

通过听觉诱发磁场以及传统心理物理方法评估双耳听力和听觉-视觉相互作用的大脑机制

基本信息

批准号：
16390483
负责人：
KAWASE Tetsuaki
金额：
$ 8.06万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

1.Binaural loudness summation: The well-known binaural effects of loudness summation, which is observed as a psychophysical phenomenon could not be verified by the N100m measurements. Although the loudness sensation considered to be related to the summed excitation level of auditory nerves, the summed potential from the auditory cortex (as N100m) might not necessarily reflect the loudness sensation.2.Signal detection in background noise : Binaural unmasking refers to the improvement in intelligibility under conditions of masking when a tone is presented out of phase rather than in phase. Psychophysical binaural unmasking can be quantitatively evaluated by magnetoencephalography (MEG) in the auditory cortex level of the bilateral hemispheres in normal healthy subjects as well as in patients with the disturbance of consciousness.3.Time-intensity trading : Time-intensity trading, which is related to the binaural ability to localize the sound, was observed under the normal condition as well as under the simulated condition of unilateral hearing disturbance. The unilateral disturbance appears to affect the time-intensity trading.4.Effect of visual input on the N100m of the auditory evoked magnetic field : Although the effects of visual input on the N100m of the auditory evoked magnetic field was observed in the present study, basically no positive effects could not been obtained.5.Neuromagnetic evidence of abnormal auditory function in children diagnosed as "functional hearing loss" : Functional hearing loss (FHL) is defined as the hearing disturbance for which there is no organic basis. In the present study, the cortical responses in patients with FHL diagnosed based on the conventional otological examinations was examined. The results suggest that some FHL patients have abnormal function at the level of auditory cortex that can be objectively evaluated by AEFs.

1.双耳响度总和：众所周知的双耳效应的响度总和，这是观察到的心理物理现象，不能验证的N100米的测量。虽然响度感觉被认为与听觉神经的总兴奋水平有关，但来自听觉皮层的总电位（如N100 m）不一定反映响度感觉。2.背景噪声中的信号检测：双耳去掩蔽是指在掩蔽条件下，当音调呈现异相而不是同相时，可懂度的改善。在正常人和意识障碍患者的双侧大脑半球听觉皮层水平上，脑磁图（MEG）可以定量评价心理物理双耳暴露。3.时间-强度交易：时间-强度交换，这与双耳定位声音的能力有关，在正常条件下和模拟单侧听力障碍条件下观察。视觉输入对听觉诱发磁场N100 m的影响：本研究虽然观察到视觉输入对听觉诱发磁场N100 m的影响，但基本上没有得到积极的影响。5.诊断为“功能性听力损失”的儿童听觉功能异常的神经磁证据：功能性听力损失（FHL）是指没有器质性基础的听力障碍。在本研究中，检查了根据常规耳科检查诊断的FHL患者的皮质反应。结果提示，部分FHL患者存在听觉皮层水平的功能异常，听觉诱发电位可以客观地评价这些功能异常。