New Insights into Joint Cartilage Degeneration and Synovitis in Rheumatoid Arthritis and Osteoarthritis. - Effects of Adrenomedullin-
对类风湿关节炎和骨关节炎中关节软骨退化和滑膜炎的新见解。
基本信息
- 批准号:16591498
- 负责人:
- 金额:$ 2.53万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2004
- 资助国家:日本
- 起止时间:2004 至 2007
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The plasma adrenomedullin and PAMP level was about twice higher than the normal level in the patient with rheumatic arthritis, in addition, adrenomedullin equal with the concentration which was included in the plasma and in the joint fluid. Synovia has higher amount of adrenomedullin than ligamentous tissues and meniscus in the joint tissues in the patient with rheumatic arthritis. These evidences lead to us the possibility of adrenomedullin acting chiefly as a hormone in vivo and suggestion of the fashion of the adrenomedullin activity mainly in synovia.In the synovia with the rheumatic arthritis, the gene expression of adrenomedullin and PAMP is confirmed, and these were composed secretion in the cultured the synovia. Moreover, the secretion of IL - 6 was significantly inhibited in addition with adrenomedullin. It was clarified that there was a significant anti-inflammatory effect in the role of adrenomedullin in the inflammatory synovium.When adrenomedullin was administered by using an anti-inflammatory effect in arthritis, in using the rabbit adjuvant arthritis model, adrenomedullin caused the reduce of the swelling, decreasing the number of the lymphocytes and promotion of fibrous change in five days after it had treated with injection into a swollen joint. Therefore, it was proven that adrenomedullin had a role as the regulator for arthritis in rheumatic arthritis.In addition normal joint chondrocytes voluminously stored adrenomedullin in the granules in its cytoplasm. In the primary cultured chondrocytes, adrenomedullin induced cell apoptosis and necrosis as a dose depended manner, and the efficiency was clarified for the cell proliferation as a local regulator in the arthritis.
风湿性关节炎患者血浆肾上腺髓质素和PAMP水平较正常人高2倍左右,且血浆和关节液中肾上腺髓质素的含量与正常人相当。风湿性关节炎患者关节组织中滑膜组织中肾上腺髓质素含量高于韧带组织和半月板组织。这些证据提示肾上腺髓质素在体内可能主要作为激素发挥作用,并提示肾上腺髓质素主要在滑膜中发挥作用的方式,在风湿性关节炎滑膜中,证实了肾上腺髓质素和PAMP的基因表达,它们在培养的滑膜中是合成分泌物。此外,除了肾上腺髓质素外,IL - 6的分泌也受到显著抑制。结果表明,肾上腺髓质素在炎症滑膜中具有显著的抗炎作用,当肾上腺髓质素用于关节炎抗炎作用时,在使用兔佐剂性关节炎模型中,肾上腺髓质素在注射到肿胀关节中后的5天内引起肿胀减轻,淋巴细胞数量减少,并促进纤维化变化。因此,肾上腺髓质素在风湿性关节炎中起关节炎调节剂的作用。另外,正常关节软骨细胞大量储存肾上腺髓质素于其细胞质的颗粒中。在原代培养的软骨细胞中,肾上腺髓质素以剂量依赖的方式诱导细胞凋亡和坏死,并阐明了作为关节炎局部调节剂的细胞增殖效率。
项目成果
期刊论文数量(57)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Evaluation of circulatory compromise in the leg in lumbar spinal canal stenosis
腰椎管狭窄症下肢循环损害的评估
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:Chosa;E
- 通讯作者:E
Increased Plasma and Joint Tissues Adrenomedullin Levels in Patients with Rheumatoid Arthritis Compared to Those with Osteoarthritis
与骨关节炎患者相比,类风湿关节炎患者的血浆和关节组织肾上腺髓质素水平升高
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:Chosa;E
- 通讯作者:E
抗原惹起型ウサギ関節炎モデルに対するアドレノメジュリンの効果
肾上腺髓质素对抗原诱导的兔关节炎模型的影响
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Hamada;H.;帖佐 悦男;大倉 俊之
- 通讯作者:大倉 俊之
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