Brain Mechanism of Aggression

攻击性的大脑机制

基本信息

批准号：
17330151
负责人：
OGAWA Sonoko
金额：
$ 9.92万
依托单位：
UNIVERSITY of TSUKUBA
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17330151/
关键词：
Aggressive Behavior Estrogen Receptors Activity Emotionality Social Investigation Anxiety-Related Behavior Serotonin

项目摘要

During the funding period, we have worked to determine the role of estrogen receptor β (ER-β) in the regulation of aggressive behavior in mice in relation to the levels of anxiety levels, social recognition and stress responsiveness.(1) In the first set of the studies, we tested the effects of estrogen replacement on the levels of anxiety in gonadectomized male mice of ER-b knockout (βERKO) as well as wild-type (WT). The levels of anxiety measured during the light-dark transition tests significantly decreased by estrogen treatment in WT, but not in βERKO, male mice. We also measured the mRNA levels of serotonin transporter (SERT) in ER-β rich midbrain dorsal raphe nuclei. Again, estrogen increased SERT mRNA levels in WT mice but it failed to do so in βERKO mice.(2) Aggressive behavior of male mice is known to first appear around the time of puberty onset at 5-6weeks of age. In our previous studies, we found an increase of aggression in PERKO mice at the pubertal age suggesting disruption of inhibitory brain system. In the second set of studies, we studied the effects of stress loading on the onset of aggressive behavior around the puberty age. Aggressive behavior measured at 5weeks of age was greatly decreased in mice those separated from their mothers during neonatal period. Decreased levels and a delayed onset of aggression at pubertal age were particularly pronounced in βERKO male mice compared to WT mice. Therefore, we concluded that ER-β might be involved in the development of stress responsiveness around the time of pubertal onset of aggression.

During the funding period, we have worked to determine the role of estrogen receptor β (ER-β) in the regulation of aggressive behavior in mice in relation to the levels of anxiety levels, social recognition and stress responsiveness.(1) In the first set of the studies, we tested the effects of estrogen replacement on the levels of anxiety in gonadectomized male mice of ER-b knockout (βERKO) as well as wild-type (WT).雌激素治疗在WT中，在浅黑暗过渡测试期间测得的焦虑水平显着降低，但在βerko，雄性小鼠中却没有显着降低。我们还测量了富含ER-β的中脑背raphe核中5-羟色胺转运蛋白（SERT）的mRNA水平。同样，雌激素在WT小鼠中提高了SERT mRNA水平，但在βerko小鼠中未能做到。（2）已知雄性小鼠的侵略性行为在5-6周的青春期发作时首次出现。在我们先前的研究中，我们发现在青春期时代的Perko小鼠的侵略性增加，这表明抑制性脑系统破坏了。在第二组研究中，我们研究了压力载荷对青春期年龄周围侵略性行为的发作的影响。在新生儿期间与母亲分离的小鼠，在5周大的年龄中测得的侵略行为大大降低。与WT小鼠相比，在βerko雄性小鼠中，青春期年龄降低和侵略性延迟发作特别明显。因此，我们得出的结论是，ER-β可能参与了侵略性开始时期的应激反应能力的发展。