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Assembling Database of Minute Surface Structure and Genetic Analysis of Amelogenesis Imperfecta in Asia

亚洲牙釉质生成不全者微小表面结构数据库的建立和遗传分析

基本信息

批准号：
17406029
负责人：
OGATA Tetsuro
金额：
$ 8.64万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

We held the symposium in regard to amelogenesis imperfecta for Chinese dentists and researchers at Beijing University in March, 2006.Dr.Wunan, who was a Chinese dentist and researcher at Beijing University Hospital, entered graduate school of Dental Science, Kyushu University in April,2006. He has started to research genetic analysis under Professor Dr.Nonaka and Associated Professor Dr.Fukumoto.The familial case of amelogenesis imperfecta was detected in China by Professor Ge Li-Hong, who is one of our collaborators. Ten people had an onset of amelogenesis imperfecta among families of 22 people over four generations. We performed oral examinations and took oral pictures of alive 18 people among the families. We took blood samples from some of them after gaining their approval, and kept them cryogenically at Beijing University. We took impressions of affected 4 children, and made two sets of plaster models. Dr.Wunan brought one of the models to our University, and started to measure the minute surface structure by non-contact laser scan device. We are taking care subjects at Beijing University Hospital. We conformed to ethical code of Beijing University. One of our collaborators at Beijing University is making some of results as a master's thesis.In November,2006,our research team who consisted of both Japanese and Beijing University had been to Xinjiang Medical University located west China, and held symposium in regard to amelogenesis imperfecta and current dental treatment for children in Japan. We asked them to look for the case of amelogenesis imperfecta.

2006年3月，我们在北京大学举办了中国牙科医生和研究人员关于釉质发生不完全的研讨会。武南博士，中国牙科医生，北京大学医院研究员，于2006年4月进入九州大学口腔科学研究生院。他在野中教授和福本副教授的指导下开始了基因分析的研究。我们的合作者之一葛力教授在中国中发现了成釉发育不全的家族性病例。在超过四代的22人家庭中，有10人出现釉质发育不全。我们进行了口腔检查，并对其中18个家庭中的活着的人进行了口腔拍照。我们在征得他们的同意后，从其中一些人身上提取了血液样本，并将其冷冻保存在北京大学。对4名患病儿童取模，制作两套石膏模型。武南博士将其中一个模型带到了我校，并开始用非接触式激光扫描仪测量微小的表面结构。我们在北京大学医院接受护理。我们遵守了北京大学的道德规范。2006年11月，我们由日本大学和北京大学组成的研究小组前往位于中国西部的新疆医科大学，就牙釉质形成不全和日本儿童牙科治疗现状召开了座谈会。我们让他们寻找釉质发育不全的病例。