Establishment and application of stress assessment system for health expectancy

健康期望压力评估体系的建立与应用

• 批准号: 17500487
• 负责人: TSUBOI Hirohito
• 金额: $ 2.34万
• 依托单位: Mie University (2006-2007)Hamamatsu University (2005)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17500487/
• 关键词: depressive symptoms; psychological stress; cortisol; IgA; chemiluminescence; oxidation; 抑うつ状態; ストレス; フォトン; 分泌型IgA; 抑うつ度; 心理的ストレス

<Aim>Depression is an object of public concern and a significant risk factor for life-style diseases, which affects health expectancy. The aim of this study was(1) to investigate associations between psychological stress and oxidative stress, and to establish assessment systems for psychosomatic stress, (2) to apply ultra-weak chemiluminescence(uwCL), an indicator of oxidative activity, to the measurement of psychological stress.<Methods>It was examined whether or not salivary uwCL, ultra-weak photons emitted from saliva, can be a sensitive biomarker for acute psychological changes. We also investigated the way to assess depressive symptoms, one of the typical responses for chronic stress, utilizing uwCL, cortisol and sIgA in saliva.<Results>Acute psychological changes induced by angry and depressive moods increased oxidative activity and transiently weaken immunity detected by salivary sIgA concentrations. In relation to chronic psychological status, morning responses of uwCL, cortisol and sIgA were measured ; consequently, the concentration and the flow rate of sIgA significantly decreased, those of cortisol increased and uwCL decreased in 30 min after awakening even after controlling for covariates.<Conclusion>We indicated temporal changes of uwCL induced by acute psychological challenges, which may be modified by trait anger. Although the association between psychological and oxidative stress was found, assessment systems for chronic psychosomatic stress remain to be elucidated.

<Aim>抑郁症是公众关注的对象，也是影响健康预期的生活方式疾病的重要风险因素。本研究的目的是（1）探讨心理应激与氧化应激之间的关系，建立心身应激的评价体系;（2）将氧化活性指标--超微弱化学发光（uwCL）应用于心理应激的测量。<Methods>研究了唾液uwCL（从唾液发射的超弱光子）是否可以是急性心理变化的敏感生物标志物。我们还研究了评估抑郁症状的方法，这是慢性应激的典型反应之一，利用唾液中的uwCL，皮质醇和sIgA。<Results>愤怒和抑郁情绪引起的急性心理变化增加了氧化活性，并暂时削弱唾液sIgA浓度检测免疫。在慢性心理状态，早晨的uwCL，皮质醇和sIgA的反应进行了测量，因此，浓度和流量的sIgA显着下降，皮质醇增加和uwCL下降，在30分钟后醒来，即使在控制协变量。<Conclusion>我们指出，急性心理挑战引起的uwCL的时间变化，这可能是由特质愤怒修改。虽然心理和氧化应激之间的关联被发现，慢性心身应激的评估系统仍有待阐明。

项目成果

Responses of ultra-weak chemiluminescence and secretory IgA in saliva to the induction of angry and depressive moods.

超弱化学发光和唾液中分泌型 IgA 对诱发愤怒和抑郁情绪的反应。

• 发表时间: 2008
• 期刊: Brain, Behavior and Immunity Vol22
• 作者: Hirohito Tsuboi;et. al.
• 通讯作者: et. al.

Therapeutic effects of color on acute psychological stress.

颜色对急性心理压力的治疗作用。

• 发表时间: 2006
• 期刊: Journal of Neuroimmunology 178・Suppl
• 作者: Kuniaki Takagi;Nobuhiro Goi;Yuko Hirai;Hitoshi Harada;Akira Ikari;Kimitsugu Nakamura;Mitsuo Hiramatsu;Hiroh ito Tsuboi;Reiko Horiki;Takahiko Ono;Naohide Kinae
• 通讯作者: Naohide Kinae

心身ストレスによる唾液微弱発光量変化への重炭酸イオンの関与

由于精神和身体压力，碳酸氢根离子参与唾液发光的变化

• 发表时间: 2006
• 期刊: 第126回 日本薬学会抄録集
• 作者: 高木邦明;五井伸博;蓮沼毅;平井優子;原田均;五十里彰;寺島結芽子;木苗直秀;中村公嗣;平松光夫;坪井宏仁;小野孝彦
• 通讯作者: 小野孝彦

Lipid peroxidation and antioxidant status concerning job stress

与工作压力相关的脂质过氧化和抗氧化状态

• 发表时间: 2005
• 期刊: Journal of Psychosomatic Research 58(suppl)
• 作者: Tsuboi H;Tatsumi A;Yamamoto K;Kinae N;Takagi K;Shimoi K;Kobayashi F
• 通讯作者: Kobayashi F

Psychological stress secrets peroxdase and thiocyanate in oral cavity quickly

心理压力使口腔迅速分泌过氧化物酶和硫氰酸盐

• 发表时间: 2006
• 作者: Nobuhiro;Goi;et. al.
• 通讯作者: et. al.