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Research on the relation ship among disease susceptibility genes, axial cognitive, psychophysiological function and brain image in schizophrenia

精神分裂症疾病易感基因与轴性认知、心理生理功能及脑图像关系的研究

基本信息

批准号：
17591211
负责人：
IWASE Masao
金额：
$ 2.37万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591211/
关键词：
schizophrenia social functionings cognitive function psychophysiology brain imagine disease susceptibility genes

项目摘要

We tested cognitive function in schizophrenia using Wechsler Memory Scale-R, WALS-R, Advanced Trail Making Test (ATMT), Wisconsin Card Sorting Test, Japanese Adult Reading Test, Continuous Performance Test and Facial Emotion Labeling Test. We assessed axial functionings in schizophrenia using Rehabilitation Evaluation Hall and Baker. Lower visuospatial working memory and processing speed assessed by ATMT was related with lower self care ability and community skill in schizophrenia. We report this finding in an English article. Lower performance in Facial Emotion Labeling Test was related with lower communication ability in schizophrenia. We reported this finding in a Japanese article. MRI images were analyzed using Voxel Based Morphometry and diffusion tensor imaging method. MEG data during working memory task and Stroop task were analyzed. During NIRS measurement, verbal fluency test (letter and category), executive function (Tower of Hanoi), working memory task and Stroop task were performed. We found diminished prefrontal activation during verbal fluency test (letter) and Tower of Hanoi in schizophrenia. We also found decreased prepulse inhibition in Japanese patients with schizophrenia. We obtained blood samples for gene analysis from 382 patients with schizophrenia, 121 healthy control subjects and 135 patients with other psychiatric disorders. We found several significant relationships among cognition, social functionings, brain images, psychophysiological function and disease susceptibility genes like DISC-1, Dysbindin, Neuregrin 1 and PACAP. This study established a basis for understanding the pathological structure of schizophrenia from gene level to psychosocial factors.

采用韦氏记忆量表、WALS-R、高级连线测验(ATMT)、威斯康星卡片分类测验、日本成人阅读测验、连续操作测验和面部情绪标记测验对精神分裂症患者的认知功能进行测试。采用康复评定量表和贝克评定量表对精神分裂症患者的轴性功能进行评估。ATMT评定的视觉空间工作记忆和加工速度低下与精神分裂症患者的自理能力和社区技能低下有关。我们在一篇英文文章中报道了这一发现。精神分裂症患者面部情绪标记测验成绩较差与沟通能力较差有关。我们在一篇日本文章中报道了这一发现。MRI图像分析采用基于体素的形态测量和扩散张量成像方法。对工作记忆任务和Stroop任务的脑磁图数据进行分析。在近红外光谱测量中，进行了语言流畅性测试(字母和类别)、执行功能(河内塔)、工作记忆任务和Stroop任务。在语言流畅性测试(Letter)和河内塔测试中，我们发现精神分裂症患者的前额叶激活减弱。我们还发现，日本精神分裂症患者的脉冲前抑制减少。我们采集了382例精神分裂症患者、121例健康对照和135例其他精神疾病患者的血液样本进行基因分析。我们发现认知、社会功能、脑成像、心理生理功能与疾病易感基因如Disk-1、dybindin、Neuregrin 1和PACAP之间存在显著的关系。本研究为从基因水平到心理社会因素了解精神分裂症的病理结构奠定了基础。