Basic study in effectiveness and safety of liquid ventilation for severe respiratory failure

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The concept of liquid ventilation (LV) has been investigated over the past three decades. Numerous studies have evaluated the ability of perfluorocarbon fluids to enhance gas exchange and pulmonary function in the setting of lung injury. The mechanism of gas exchange is quite different during between gas ventilation and liquid ventilation. However there are very few studies to investigate the setting of ventilation to maximum gas exchange and pulmonary function during liquid ventilation. In this study, we performed a basic study for electiveness and safety of liquid ventilation in a rat model First, P_aCO2 and P_aO2 were analyzed during between gas ventilation and partial liquid ventilation in the various operational conditions (minute volume: 167, 200, 267 mL/min, respiratory rate: 40, 50, 60, 70, 80, 90 /min, I : E : 1 : 2, 1 : 1). Second, the effect of ventilation settings to gas exchange and pulmonary function were compared during between gas ventilation and partial liquid ventilation in a rat model. It was revealed that the effect of ventilation settings to gas exchange and pulmonary function during liquid ventilation is larger than during gas ventilation. We conclude that gas exchange and pulmonary function such as P_aCO2 and P_aO2 should be monitored carefully during liquid ventilation in the treatment of the patients with severe respiratory failure.