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Basic study in effectiveness and safety of liquid ventilation for severe respiratory failure

液体通气治疗严重呼吸衰竭有效性和安全性的基础研究

基本信息

批准号：
17591884
负责人：
MATSUDA Kenichi
金额：
$ 2.44万
依托单位：
University of Yamanashi
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591884/
关键词：
respiratory failure lung injury liquid ventilation artificial ventilatory support fluorocarbon Emergency medicine intensive care medicine critical care medicine

项目摘要

The concept of liquid ventilation (LV) has been investigated over the past three decades. Numerous studies have evaluated the ability of perfluorocarbon fluids to enhance gas exchange and pulmonary function in the setting of lung injury. The mechanism of gas exchange is quite different during between gas ventilation and liquid ventilation. However there are very few studies to investigate the setting of ventilation to maximum gas exchange and pulmonary function during liquid ventilation. In this study, we performed a basic study for electiveness and safety of liquid ventilation in a rat model First, P_aCO2 and P_aO2 were analyzed during between gas ventilation and partial liquid ventilation in the various operational conditions (minute volume: 167, 200, 267 mL/min, respiratory rate: 40, 50, 60, 70, 80, 90 /min, I : E : 1 : 2, 1 : 1). Second, the effect of ventilation settings to gas exchange and pulmonary function were compared during between gas ventilation and partial liquid ventilation in a rat model. It was revealed that the effect of ventilation settings to gas exchange and pulmonary function during liquid ventilation is larger than during gas ventilation. We conclude that gas exchange and pulmonary function such as P_aCO2 and P_aO2 should be monitored carefully during liquid ventilation in the treatment of the patients with severe respiratory failure.

液体通气（LV）的概念在过去的三十年里一直在研究。许多研究评估了全氟化碳液体在肺损伤情况下增强气体交换和肺功能的能力。气体通气与液体通气时气体交换的机理有很大的不同.然而，很少有研究探讨液体通气期间最大气体交换和肺功能的通气设置。本研究在大鼠模型上对液体通气的选择性和安全性进行了基础性研究。首先，在不同的操作条件下，分析了气体通气和部分液体通气之间的P_aCO_2和P_aO_2（分钟通气量：167、200、267 mL/min，呼吸频率：40、50、60、70、80、90 /min，I：E：1：2、1：1）。第二，在大鼠模型上比较气体通气和部分液体通气期间通气设置对气体交换和肺功能的影响。结果表明，液体通气时通气设置对气体交换和肺功能的影响大于气体通气时。结论：重症呼吸衰竭患者在液体通气治疗过程中，应密切监测气体交换和肺功能，如P_aCO_2、P_aO_2。