Study on compensatory change of masticator muscle using masseter muscle suppression

咬肌抑制对咀嚼肌代偿性变化的研究

• 批准号: 17592015
• 负责人: FURUUCHI Toshi
• 金额: $ 1.82万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17592015/
• 关键词: mastication; masticator muscle; masseter muscle; compensatory change

1. Purpose Mastication needs cooperation of masticatory muscles, but the exact role of the each muscle for mastication is not completely clear. The purpose of this study was to evaluate the change of masticatory muscles under the unilateral masseter muscle dysfunction induced by Botulinum toxin A (BTXA) injection in rabbits. BTXA binds to presynaptic nerve endings and inhibits the release of acetylcholine, leading to temporary partial denervation and reduction of muscle fiber.2. Materials and Methods White Japanese rabbits were injected with 10 units of BTXA into the left masseter muscle. The effect of a neuromuscular blockade of masseteric activity was evaluated with serial computer tomography (CT) scans with 0.63mm slice thickness and 0.1mm slice interval taken after 4 weeks.3. Results The masseter muscle size of BTXA injected was reduced to about 80% against the control side. This indicated the morphologic change caused by the neuromuscular blockade.4. Coclusion To study the exact role of each muscles for mastication, masseter mucle dysfunction was made by BTXA injection into the masseter muscle. The most suitable dose, timing and the degree of dysfunction were established. The elrctro-myography is considered to investigate the functional change. This animal model helps the understanding of the mechanism of tempolo-mandibular dysfunction.

1. 目的咀嚼需要咀嚼肌的配合，但各肌肉在咀嚼中的确切作用尚不完全清楚。本研究旨在探讨肉毒毒素A （BTXA）注射引起的单侧咬肌功能障碍对兔咀嚼肌的影响。肉毒毒素与突触前神经末梢结合，抑制乙酰胆碱的释放，导致暂时性部分失神经支配和肌肉纤维减少。材料与方法将10单位肉毒毒素注射于大白兔左咬肌。神经肌肉阻断对咬肌活动的影响通过连续计算机断层扫描（CT）评估，扫描厚度为0.63mm，间隔0.1mm， 4周后进行扫描。结果注射BTXA后，咬肌大小比对照组缩小80%左右。这表明神经肌肉阻滞引起的形态学改变。结论通过在咬肌内注射肉毒毒素，观察咬肌在咀嚼过程中的作用。确定最合适的剂量、时间和功能障碍程度。肌电图被认为是研究功能改变的方法。该动物模型有助于了解颞下颌功能障碍的机制。

项目成果

A case of masticatory disturbance incidental to trigeminal schwannoma: changes in occlusal force and masticatory sensation before and after radiosurger

三叉神经鞘瘤并发咀嚼障碍一例：放射外科手术前后咬合力和咀嚼感觉的变化

• 发表时间: 2007
• 作者: Iikubo M;ed. al.
• 通讯作者: ed. al.

頸部リンパ節に多発した胚中心進展性異形成の一例

颈部多发淋巴结生发中心进行性发育不良1例

• 发表时间: 2007
• 期刊: 歯科放射線 47
• 作者: 飯久保正弘; 他
• 通讯作者: 他

BIRTH DEFECTS : NEW RESEARCH (Chapter VII)

出生缺陷：新研究（第七章）

• 发表时间: 2006
• 作者: Toshi FURUUCHI ;et. al.;Toshi FURUUCHI ed. al.;Toshi FURUUCHI et al.
• 通讯作者: Toshi FURUUCHI et al.

A case of masticatory disturbance incidental to trigeminal schwannoma: changes in occlusal force and masticatory sensation before and after radiosurgery

三叉神经鞘瘤并发咀嚼障碍一例：放射外科治疗前后咬合力及咀嚼感觉的变化

• 发表时间: 2008
• 期刊: The British Journal of Radiology 81
• 作者: Iikubo M;et. al.
• 通讯作者: et. al.

BIRTH DEFECTS: NEW RESEARCH Chapter VII Maxillofacial Manifestations of Cleidocranial Dysplasia, Concentrating on Masseter Muscle Change.

出生缺陷：新研究第七章锁骨颅骨发育不良的颌面表现，重点关注咬肌变化。

• 发表时间: 2006
• 作者: Toshi FURUUCHI ;et. al.
• 通讯作者: et. al.