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STUDY ON THE DEVELOPMENT OF THE SCORE AS AN INDEX FOR THE EEFECT OF POLYPHENOL-CONTAINING FOODS ON THE REDUCTION OF BLOOD GLUCOSE LEVEL

含多酚食品降低血糖效果指数的研究

基本信息

批准号：
18500627
负责人：
TSUJI Hideaki
金额：
$ 2.57万
依托单位：
Okayama Prefectural University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

Life-style-induced disease is a critical social problem. Diabete is one of the life-style-induced diseases. The disease consists of two types, namely I-type which is dependent on insulin, and IItype, which is nondependent on insulin. The latter type accounts for more than 95% of total diabetic patients. In order to cure and prevent the omset of the insuline-nondependent, a drug such as Acalbose and functional foods including functional components such as wheat albumin, quava polyphenol and digestion-resitant polydextrose have been utilized At present, other functional components than the above-mentioned components are expected to be developed.In order to establish an index assessing the effect of polyphenol-containing foods on reduction of blood glucose level, it is very important to elucidate the functional components in the foods responsible for the reduction of blood glucose level We carried out the investigation on polyphenol compounds in foods actively. Consequently, we found out chlorogenic acid as a functional components inducing the reduction of blood glucose level Furthermore, catechins and quercetin were shown to show the functionality inducing the reduction of blood glucose level o among the known polyphenol compounds. Interestingly, these polyphenol components were shown to exhibit the regulation of the blood glucose level by inhibition α-glucosidase activity such as sucrase and maltase.We found out the occurrence of chlorogenic acid derivatives in the leavers of white sweet potato called Kibimidori in Okayama region. These chlorogenic acid derivatives were shown to show more powerful inhibitory activity for α-glucosidase activity than chlorogenic acid, quecetin and catechins. This finding indicates that these components are candidate as afunctional components responsible for the reduction of blood glucose level.

生活方式引起的疾病是一个严重的社会问题。糖尿病是生活方式引起的疾病之一。该病分为两型，即依赖胰岛素的I型和不依赖胰岛素的II型。后者占糖尿病患者总数的95%以上。为了治疗和预防非胰岛素依赖性的失眠，已经使用了药物如阿卡波糖和功能性食品，所述功能性食品包括功能性组分如小麦白蛋白、番石榴多酚和抗消化性聚葡萄糖。目前，为了建立评价多酚类化合物的效果的指标，食品中多酚类化合物对降低血糖水平的作用，阐明食品中具有降血糖作用的功能成分是非常重要的。因此，我们发现绿原酸作为诱导血糖水平降低的功能组分。此外，在已知的多酚化合物中，儿茶素和槲皮素显示出诱导血糖水平降低的功能。有趣的是，这些多酚成分显示出通过抑制蔗糖酶和麦芽糖酶等α-葡萄糖苷酶活性来调节血糖水平。我们发现在冈山地区称为Kibimidori的白色甘薯叶中存在绿原酸衍生物。这些绿原酸衍生物对α-葡萄糖苷酶活性的抑制作用强于绿原酸、槲皮素和儿茶素。这一发现表明这些成分是负责降低血糖水平的功能成分的候选者。