Novel treatment for menopausal symptoms following surgery and adjuvant chemotherapy for premenopausal breast cancer -eficacy and safety in Kampo Medicine

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Preliminary study:Characteristics of 6 patients who were treated with TJ-67 were summarized in Table 1. Their menopausal symptoms were mainly vasomotor symptoms such as hot flushes and sweating, and mental symptoms such as sleeping disorder and depression, but not skeletal muscle symptoms such as shoulder stiffness. In 5 of 6 patients, the treatment of TJ-67 resulted in a noticeable improvement in menopausal symptoms without adverse effects, although one patient (No.5 in Table 1) reported that her symptoms did not change. Changes in the serum levels of E2 are shown in Figure 1. The serum E2 levels in 5 patients did not change, but there was an increase in serum E2 level in one patient (No.6 in Table 1), who was successfully treated with TJ-67. In this patient, the administration of TJ-67 was discontinued and her serum E2 level decreased.Case ReportWe report a 39-year-old woman with premenopausal breast cancer who developed estrogen-deficiency symptoms accompanying chemotherapy- related amenorrhea, and was successfully treated with Nyoshinsan/ TJ-67, traditional herbal medicine ( Kampo ). Furthermore, 6 breast cancer survivors with menopausal symptoms were also treated with TJ-67, and 5 of 6 patients showed noticeable improvement without adverse effects. Since managing estrogen-deficiency symptoms in breast cancer survivors is still problematic, Nyoshinsan/TJ-67 may be a useful and safe agent for estrogen-deficiency symptoms in breast cancer survivors.