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Novel treatment for menopausal symptoms following surgery and adjuvant chemotherapy for premenopausal breast cancer -eficacy and safety in Kampo Medicine

绝经前乳腺癌手术和辅助化疗后更年期症状的新疗法 - 汉方医学的疗效和安全性

基本信息

批准号：
18590651
负责人：
KOGURE Toshiaki
金额：
$ 2.17万
依托单位：
Gunma University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590651/
关键词：
After operation of Breast cancer Nyoshinsan Kampo Medicine E2 E2 receptor Menopausal Symptom anti-hormone Therapy

项目摘要

Preliminary study:Characteristics of 6 patients who were treated with TJ-67 were summarized in Table 1. Their menopausal symptoms were mainly vasomotor symptoms such as hot flushes and sweating, and mental symptoms such as sleeping disorder and depression, but not skeletal muscle symptoms such as shoulder stiffness. In 5 of 6 patients, the treatment of TJ-67 resulted in a noticeable improvement in menopausal symptoms without adverse effects, although one patient (No.5 in Table 1) reported that her symptoms did not change. Changes in the serum levels of E2 are shown in Figure 1. The serum E2 levels in 5 patients did not change, but there was an increase in serum E2 level in one patient (No.6 in Table 1), who was successfully treated with TJ-67. In this patient, the administration of TJ-67 was discontinued and her serum E2 level decreased.Case ReportWe report a 39-year-old woman with premenopausal breast cancer who developed estrogen-deficiency symptoms accompanying chemotherapy- related amenorrhea, and was successfully treated with Nyoshinsan/ TJ-67, traditional herbal medicine ( Kampo ). Furthermore, 6 breast cancer survivors with menopausal symptoms were also treated with TJ-67, and 5 of 6 patients showed noticeable improvement without adverse effects. Since managing estrogen-deficiency symptoms in breast cancer survivors is still problematic, Nyoshinsan/TJ-67 may be a useful and safe agent for estrogen-deficiency symptoms in breast cancer survivors.

初步研究：表1总结了6例接受TJ-67治疗的患者的特征。绝经期症状以潮热、出汗等血管症状和睡眠障碍、抑郁等精神症状为主，而肩关节僵硬等骨骼肌症状较少。在6名患者中的5名中，TJ-67治疗导致更年期症状的明显改善而没有副作用，尽管一名患者（表1中的第5名）报告她的症状没有改变。血清E2水平的变化见图1。5名患者的血清E2水平没有变化，但1名患者（表1中的6号）的血清E2水平升高，该患者成功地用TJ-67治疗。在这个病人中，TJ-67的管理被中断，她的血清E2水平reduced.Case Report我们报告一个39岁的妇女绝经前乳腺癌谁开发雌激素缺乏症的症状伴随化疗相关的闭经，并成功地治疗与Nyoshinsan/ TJ-67，传统的草药（汉方）。此外，6名患有绝经期症状的乳腺癌幸存者也接受了TJ-67治疗，6名患者中有5名表现出明显的改善，无不良反应。由于管理乳腺癌幸存者的雌激素缺乏症症状仍然存在问题，Nyoshinsan/TJ-67可能是乳腺癌幸存者雌激素缺乏症症状的有用和安全的药物。