Implantation of Silmet Stents for Malignant Airway Stenosis

Silmet 支架植入治疗恶性气道狭窄

• 批准号: 18590872
• 负责人: MIYAZAWA Teruomi
• 金额: $ 1.83万
• 依托单位: St.Marianna University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590872/
• 关键词: Airway stenosis; Airway stent; Hybrid stent; Respiratory physiology

Purpose :Metallic stents prove useful if the stenosis is inaccessible by rigid bronchoscope or if prior dilation or laser resection of stenosis is difficult However, disadvantages such as the removal of stents, replacement of stents, and the deterioration of long-term placements exist. Silmet stent (Novatech, France), a new metallic (nitinol) expandable stent with fully covered polyester membrane, has been developed. This study was undertaken to assess the Silmet stent for its efficacy and safety.Methods :Between March 2006 and October 2007, 16 Silmet stents were placed in 10 patients with inoperable central airway stenosis due to malignant tumors using flexible and/or rigid bronchoscope under fluoroscopy and endoscopy. Patient population consisted of 7 males and 3 females(mean age 65.9 years) and stenting was performed under intraveneous anesthesia in operating rooms.Results :After implantation of the stent, immediate relief of dyspnea was achieved in 7 patients. The dyspnea index evaluated by the MRC scale, showed significant improvements after stenting. (pre vs. post P<0.05). Also, FEV1 showed a marked improvement (P<0.05), and flow volume loops, although not remarkable, showed some improvements after stenting. No complications presented during stenting, however complications such as tumor overgrowth (1) and restenosis from granulations at both ends of the stent (1) occurred post-stenting. In 1 case, stent removal was possible after radio-chemotherapy.Conclusions :In this study, the placement of Silmet stents demonstrated dyspnea relief could be achieved in patients with minimal complications.

目的：金属支架被证明是有用的，如果狭窄是不可接近的刚性支气管镜或如果以前的扩张或激光切除狭窄是困难的，但是，缺点，如支架的移除，更换支架，和长期放置的恶化存在。Silmet支架（Novatech，法国）是一种新型金属（镍钛诺）可扩张支架，具有全覆盖聚酯膜。本研究进行了评估Silmet支架的有效性和safety.Methods：2006年3月至2007年10月，16 Silmet支架放置在10例因恶性肿瘤而无法手术的中央气道狭窄患者，使用柔性和/或刚性支气管镜下透视和内窥镜。结果：7例患者在静脉麻醉下于手术室行支架植入术，术后呼吸困难立即缓解。通过MRC量表评估的呼吸困难指数显示支架植入术后显著改善。(pre与术后相比P<0.05）。FEV 1也有明显改善（P<0.05），血流量环虽然不明显，但也有一定改善。支架植入术期间未出现并发症，但支架植入术后发生了肿瘤过度生长（1）和支架两端肉芽形成再狭窄（1）等并发症。在1例患者中，支架取出后可能放化疗。结论：在这项研究中，Silmet支架的放置表明，呼吸困难的缓解，可以达到最低限度的并发症。

项目成果

気管支鏡的治療

支气管镜治疗

• 发表时间: 2008
• 期刊: 医学のあゆみ 224
• 作者: 栗本 典昭;他
• 通讯作者: 他

The best choice for stenting the bronchial tree(Silmet Stents, and Dumon Stents)

支气管树支架的最佳选择（Silmet支架、Dumon支架）

• 发表时间: 2006
• 作者: Hiroki Nishine;Teruomi Miyazawa;Hiroki Nishine;Teruomi Miyazawa;Teruomi Miyazawa
• 通讯作者: Teruomi Miyazawa

悪性腫瘍による高度中枢気道狭窄に対するSiLmetStent留置の有用性

SiLmetStent 置入术在恶性肿瘤引起的严重中央气道狭窄中的作用

• 发表时间: 2008
• 期刊: 気管支学 30
• 作者: 古屋 直樹;他14名
• 通讯作者: 他14名

Airway stents for Malignant Stenosis

用于恶性狭窄的气道支架

• 发表时间: 2007
• 期刊: oncological emergency 4
• 作者: 西根 広樹;他13名;Teruomi Miyazawa;Teruomi Miyazawa;Teruomi Miyazawa;Teruomi Miyazawa
• 通讯作者: Teruomi Miyazawa

Implantation of Silmet Stents for Malignant Airway Stenosis

Silmet 支架植入治疗恶性气道狭窄

• 发表时间: 2008
• 期刊: JJSRE. 30
• 作者: Naoki Furuya;Teruomi Miyazawa.
• 通讯作者: Teruomi Miyazawa.