Magnetoencepharographic analyses by spatial filtering for child patients with epilepsy

癫痫儿童患者的空间滤波脑磁图分析

• 批准号: 18591136
• 负责人: SHIRAISHI Hideaki
• 金额: $ 2.5万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591136/
• 关键词: Epilepsy; Children; Magnetoencephalography; Spatial filtering analysis; Epileptic syndrome

One hundred nine patients underwent magnetoencephalographic (MEG) study. MEG data were collected by 306ch helmet-shape gradiometers (Vector View System, Neuromag Oy Stockholm, Sweden) with 600 Hz sampling rate at Hokkaido University Hospital.According to classification of epileptic types and syndromes by International League against Epilepsy (1987), subjective patients were classified as following: 85 cases with symptomatic localization related epilepsy (SLRE), 15 cases with idiopathic localization related epilepsy (ILRE), 2 cases with symptomatic generalized epilepsy (SGE) and 2 cases with idiopathic generalized epilepsy (IGE).Conventional single dipole analysis could solve the data sets of 83 cases (65 cases with SLRE, 12 cases with ILRE, 3 cases with SGE, a case with IGE, 2 cases with UDE) with significant clustering of equivalent current dipoles in a specific gyrus in cerebral cortex, and with confirmation in their seizure manifestation and other electro-clinical findings.Then we u … More sed spatial filtering analysis: dynamic statistical parametric mapping (dSPM) for the rest of cases and 16 cases (10 cases with SLRE, 3 cases with ILRE, 2 cases with SGE, a case with IGE) with multi-focal or widespread epileptiform activities could be evaluated reasonably as multi-focal or widespread distribution of MEG activities.Finally we applied time frequency analysis: short time Fourier transforms (SFT) for remaining 10 cases with low amplitude rhythmic magnetoencephalographic epileptiform activities and it showed the significant epileptogenic area, since the distribution of rhythmic activities were well correlated to the demonstration of ictal onset area.By means of single dipole analysis, spatial filtering analysis: dSPM and time-frequency analysis: SFT successfully demonstrated the distribution of the epileptogenic area in patients with epilepsy MEG analysis was supposed to be useful for almost every patient with epilepsy for presurgical evaluation or the diagnosis of the epileptic syndromes. Less

109例患者进行了脑磁图(MEG)检查。采用瑞典斯德哥尔摩Neuromag公司生产的306ch头盔状梯度仪，采样率为600 Hz。根据1987年国际抗癫痫联盟对癫痫类型和证候的分类，对85例症状性定位相关癫痫(SLRE)、15例特发性定位相关癫痫(ILRE)、2例症状性全身性癫痫(SGE)和2例特发性全身性癫痫(IGE)患者进行脑磁图分析。常规单偶极子分析可解决83例(SLRE 65例，ILRE 12例，SGE 3例，IGE 1例，ILRE 1例，IGE 1例)的脑磁图数据超声心动图2例)大脑皮质特定回等流偶极子明显聚集，并证实其癫痫表现和其他电临床表现。然后进行…检查更精细的空间滤波分析：对其余病例和16例(SLRE 10例，ILRE 3例，SGE 2例，IGE 1例)多灶性或广泛性癫痫样活动的动态统计参数映射(DSPM)可以合理地评价为MEG活动的多灶性或广泛性分布。最后，对其余10例低幅度节律性脑电癫痫活动进行了时频分析：短时傅立叶变换(SFT)，它显示了显著的致痫区域，因为节律活动的分布与发作区的显示很好地相关。通过单偶极子分析，空间滤波分析：dSPM和时频分析：SFT成功地显示了癫痫患者的致痫区域分布，MEG分析几乎适用于每一位癫痫患者的术前评估或癫痫综合征的诊断。较少

项目成果

Clinical trial of MEG analysis for epileptic patient with widespread cortical dysplasia in frontal lobe. -How can we demonstrate and evaluate wide spread rhythmic MEG activities?-

额叶广泛皮质发育不良癫痫患者 MEG 分析的临床试验。

• 发表时间: 2006
• 作者: Hideaki Shiraishi ;et. al.
• 通讯作者: et. al.

Possible involvement of the tip of temporal lobe in Landau-Kleffner syndrome

Landau-Kleffner 综合征可能累及颞叶尖端

• 发表时间: 2007
• 期刊: Brain and Development 29
• 作者: Egawa K;Asahina N;Shiraishi H;Kamada K;Takeuchi F;Nakane S;Sudo A;Kohsaka S;Saitoh S.;Hideaki Shiraishi
• 通讯作者: Hideaki Shiraishi

Long-term sequential magnetoencephalographic analyses patients with atypical benign partial epilepsy in childhood

长期序贯脑磁图分析儿童非典型良性部分性癫痫患者

• 发表时间: 2007
• 期刊: International Congress Series 1300
• 作者: Egawa K;Asahina N;Shiraishi H;Kamada K;Takeuchi F;Nakane S;Sudo A;Kohsaka S;Saitoh S.;Hideaki Shiraishi;Hideaki Shiraishi
• 通讯作者: Hideaki Shiraishi

全般性てんかんか、局在関連てんかんか?

是全身性癫痫还是局部性癫痫？

• 发表时间: 2007
• 作者: Hideaki Shiraishi ;et. al.;白石秀明;白石秀明;白石秀明
• 通讯作者: 白石秀明

Long-term sequential magnetoencephalographic analyses for patients with atypical benign partial epilepsy in childhood.

对儿童期非典型良性部分性癫痫患者进行长期序贯脑磁图分析。

• 发表时间: 2007
• 期刊: International Congress Series 1300
• 作者: Shiraishi H;Egawa K;Asahina N;Nakane S;Udo Y;Satake A;Kohsaka S;Saitoh S.
• 通讯作者: Saitoh S.