Skin regeneration : hair follicle as a model fir signal trunsduction

皮肤再生：毛囊作为冷杉信号传导的模型

• 批准号: 18591245
• 负责人: ITAMI Satoshi
• 金额: $ 2.53万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591245/
• 关键词: leptin; STAT3; keratinocvte; dermal papilla cell; Hair cycle; androgen; Hic-5; ARA55

One of the typical examples of the signal transduction in the human hair cycle progression is androgen-androgen receptor system. We developed an in vitro coculture system using DPC and follicular epithelial cells. Androgen-inducible TGF-β1 derived from DPCs plays a central role for the growth suppression. Ketoconazol inhibited androgen induced androgen receptor transactivity, and showed clinical improvement of androgenetic alopecia. We also found that androgen receptor co-activator Hic5/ARA55 regulate the androgen sensitivity in dermal papilla cells.Stat3 plays a crucial role in transducing a signal for the anagen initiation and wound healing. The anagen initiation represents vertical wound healing. Leptin strongly activates stat3 in the keratinocytes and promoted growth of keratinocytes. Db/Db mice showed the retardation of second anagen initiation, and leptin injection promoted anagen entry in Ob/Ob and normal mice. Leptin would be a potential therapeutic approach for the treatment of alopecia.

人类毛发周期进程中信号转导的典型例子之一是雄激素-雄激素受体系统。我们开发了一种使用 DPC 和滤泡上皮细胞的体外共培养系统。来自 DPC 的雄激素诱导型 TGF-β1 在生长抑制中发挥着核心作用。酮康唑抑制雄激素诱导的雄激素受体活性，并显示雄激素性脱发的临床改善。我们还发现雄激素受体共激活剂 Hic5/ARA55 调节真皮乳头细胞中的雄激素敏感性。Stat3 在转导毛发生长初期启动和伤口愈合的信号中起着至关重要的作用。毛发生长初期代表垂直伤口愈合。瘦素强烈激活角质形成细胞中的stat3并促进角质形成细胞的生长。 Db/Db 小鼠表现出第二次毛发生长初期起始延迟，瘦素注射促进 Ob/Ob 和正常小鼠进入毛发生长初期。瘦素将是治疗脱发的潜在治疗方法。

项目成果

Leptin is a paracrine regulator on hair cycle

瘦素是毛发周期的旁分泌调节剂

• 发表时间: 2007
• 作者: Sumikawa Y;Inui S;Nakajima T;Itami S
• 通讯作者: Itami S

疾患解明Overview-男性型脱毛症の病態と治療戦略

病情解析概述-雄激素性脱发的病理及治疗策略

• 发表时间: 2007
• 期刊: 実験医学 25
• 作者: 板見 智;乾 重樹;中島武之
• 通讯作者: 中島武之

Overview-Androgenetic alopecia : pathomechanism and treatment

概述-雄激素性脱发：发病机制和治疗

• 发表时间: 2007
• 期刊: JIKKENNIGAKU Vol.25
• 作者: Satoshi;I
• 通讯作者: I

機能性化粧品素材開発のための実験法

功能性化妆品材料开发的实验方法

• 发表时间: 2007
• 作者: Sumikawa Y;Inui S;Nakajima T;Itami S;板見 智
• 通讯作者: 板見 智

Androgen receptor co-activator Hic-5/ARA55 as a molecular regulator of androgen sensitivity in dermal papilla cells of human hair follicles

• DOI: 10.1038/sj.jid.5700883
• 发表时间: 2007-10-01
• 期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY
• 影响因子: 6.5
• 作者: Inui, Shigeki;Fukuzato, Yoko;Itami, Satoshi
• 通讯作者: Itami, Satoshi