Skin regeneration : hair follicle as a model fir signal trunsduction

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One of the typical examples of the signal transduction in the human hair cycle progression is androgen-androgen receptor system. We developed an in vitro coculture system using DPC and follicular epithelial cells. Androgen-inducible TGF-β1 derived from DPCs plays a central role for the growth suppression. Ketoconazol inhibited androgen induced androgen receptor transactivity, and showed clinical improvement of androgenetic alopecia. We also found that androgen receptor co-activator Hic5/ARA55 regulate the androgen sensitivity in dermal papilla cells.Stat3 plays a crucial role in transducing a signal for the anagen initiation and wound healing. The anagen initiation represents vertical wound healing. Leptin strongly activates stat3 in the keratinocytes and promoted growth of keratinocytes. Db/Db mice showed the retardation of second anagen initiation, and leptin injection promoted anagen entry in Ob/Ob and normal mice. Leptin would be a potential therapeutic approach for the treatment of alopecia.