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Conelation between degree of differentiation of hepatocellular carcinoma and signal intensity of diffusion-weigted images on 3T MR imaging

肝细胞癌分化程度与3T MR成像弥散加权图像信号强度的相关性

基本信息

批准号：
18591341
负责人：
MAETANI Youji
金额：
$ 2.53万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591341/
关键词：
Hepatocellular carcinoma degree of differentiation MR imaging diffusion weighted images 予後 3T超高磁場MRI

项目摘要

Background: The degree of differentiation of hepatocellular carcinoma (HCC) is reported one of the most important factor that affect the prognosis of patients. Especially, in liver transplantation, the prognosis is reported very poor in patients with poorly-differentiated HCC Therefor, it is very important to speculate the degree of differentiation of HCC preoperatively by radiological technique. Very recently, there a few reports that there may be certain correlation between degree of differentiation of HCC and signal intensity of diffusion-weighted images of MR imaging. In addition, 3T MR imaging can become available in the upper abdominal region recently.Purpose: To investigate if there is correlation between degree of diffirentiation of HCC and signal intensity of diffusiorr weighted images of 3T MR imaging.Material and Methods: From 2007.5.11 to 2008.3.20, consecutive 52 patients who underwent hepatectomy or liver transplantation for HCC. The mean age was 57.3 years old. Respiratory triggered diffusion weighted images was performed based on the EM sequence. The scan parameters were as follows: TE=71, b value=0.500.1000. SENSE (turbo factor =2). The signal intensity was evaluated quantitatively in a 5-poiny scale by the consensus of three radiologists. Pathological analysis was performed by one liver pathologist and divided into well, moderate, poorly differentiated HCC. Statistical analysis was underwent Spearman rank correlation.Results: Them was a good correlation between degree of differentiation of HCC and signal intensity of diffusion-weighted images of MR imaging with the "r"=0.634 and p<0.001.Conclusion : The diffusion weighted images was considered very useful to speculate the degree of differentiation of HCC. It may influence the theraputic strategy of HCC.

背景资料：肝癌的分化程度是影响患者预后的重要因素之一。特别是在肝移植中，低分化肝癌患者的预后极差，因此术前通过影像学技术推测肝癌的分化程度是非常重要的。近年来，有报道指出肝细胞癌的分化程度与磁共振弥散加权像的信号强度之间可能存在一定的相关性。材料与方法：2007年5月11日至2008年3月20日，对52例原发性肝癌患者行肝切除术或肝移植术后行3T磁共振弥散加权成像（3T MR），观察3T MR信号强度与肝癌分化程度的关系。平均年龄57.3岁。基于EM序列进行呼吸触发弥散加权成像。扫描参数如下：TE=71，B值=0.500.1000。SENSE（涡轮系数=2）。信号强度由三位放射科医生以5分制进行定量评估。由一名肝脏病理学家进行病理分析，并分为高、中、低分化HCC。结果：HCC的分化程度与MR扩散加权像信号强度呈良好的相关性，r =0.634，p<0.001。结论：扩散加权像对HCC的分化程度有很好的预测作用。它可能影响肝癌的治疗策略。