权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Sentinel node mapping guide by indocyanine green fluorescence imaging in gastrointestinal cancers

吲哚菁绿荧光成像指导胃肠癌前哨淋巴结定位

基本信息

批准号：
18591485
负责人：
MITSUO Kusano
金额：
$ 2.35万
依托单位：
Showa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591485/
关键词：
gastric cancer colorectal cancer sentinel node indocyanine green fluorescence infrared ray light

项目摘要

At first, sentinel node (SN) mapping guided by indocyanine green (ICG) fluorescence imaging was conducted in 22 patients with gastric cancer and 26 patients with colorectal cancer who had undergone standard surgical resection. Immediately after the ICG injection, lymphatic vessels draining the tumor and round-shaped SNs were visualized by their bright fluorescence. Even SNs that were not green in color could be easily and clearly visualized by ICG fluorescence imaging. The SN detection rate was 90.9% in patients with gastric cancer, and 88.5% in patients with colorectal cancer. The preliminary results show that ICG fluorescence imaging allows easy, highly sensitive and real-time imaging-guided SN mapping in patients with gastric or colorectal cancer. (Dig Surg 2008 ; 25 : 103-8)Secondly, SN mapping guided by ICG fluorescence imaging was conducted in 56 patients with gastric cancer. cT1-stage cancers were associated with a significantly higher accuracy rate (97.2% vs. 72.2%, P=0.0127) t … More han cT2-or cT3-stage cancers. A false-negative rate was 14.3% in cT1-stage cancers and 50.0% in cT2-or cT3-stage cancers, respectively. These data suggest that SN mapping guided by ICG fluorescence imaging might be useful for predicting the metastatic status in lymph nodes in cases of gastric cancer, especially those with cT1-stage cancer. (Ann Surg 2009 ; 249 : 58-62)Finally, SN mapping guided by ICG fluorescence imaging was conducted in 77 patients with cT1-or cT2-stage gastric cancer who had undergone laparoscopy-assisted gastrectomy (LAG group ; 38 patients) or conventional open gastrectomy (OG group ; 39 patients). The detection rate and mean number of fluorescent nodes (FNs) were 94.7% and 7.9, respectively, in the LAG group, and 94.9% and 7.2, respectively, in the OG group. The accuracy and false-negative rates were 97.2% and 25%, respectively, in the LAG group, and 91.9% and 23.1%, respectively, in the OG group. Among 33 LAG group patients and 27 OG group patients without SN metastasis, lymph node metastasis was found only in non-SNs located in the same lymphatic basin as the detected SNs. These data suggest that dissection of the lymphatic basin containing SNs with laparoscopic surgery may be a promising approach as a new type of minimally invasive surgery for patients with cT1- or cT2-stage gastric cancer having no metastasis in SNs. (Ann Surg Oncol 2010 Feb 17 ; Epub ahead of print) Less

首先，在吲哚菁绿色（ICG）荧光成像引导下，对22例胃癌和26例结直肠癌患者进行了前哨淋巴结（SN）标测。在ICG注射后，立即通过其明亮的荧光可视化引流肿瘤的淋巴管和圆形SN。甚至颜色不是绿色的SN也可以通过ICG荧光成像容易且清楚地可视化。胃癌患者SN检出率为90.9%，结直肠癌患者SN检出率为88.5%。初步结果表明，ICG荧光成像允许在胃癌或结直肠癌患者中进行简单、高灵敏度和实时的成像引导SN标测。(Dig Surg 2008 ; 25：103-8）其次，在56名胃癌患者中进行了由ICG荧光成像引导的SN标测。cT 1期癌症与显著更高的准确率相关（97.2% vs. 72.2%，P=0.0127）， ...更多信息 cT 2或cT 3期癌症。cT 1期肿瘤的假阴性率为14.3%，cT 2或cT 3期肿瘤的假阴性率分别为50.0%。这些数据表明，由ICG荧光成像引导的SN映射可能有助于预测胃癌，特别是cT 1期胃癌的淋巴结转移状态。(Ann 2009年外科学;二百四十九：58-62）最后，在77例接受腹腔镜辅助胃切除术（LAG组; 38例患者）或传统开放式胃切除术（OG组; 39例患者）的cT 1或cT 2期胃癌患者中进行了ICG荧光成像引导的SN标测。LAG组的检出率和荧光结节（FN）平均数分别为94.7%和7.9，OG组分别为94.9%和7.2。LAG组的准确率和假阴性率分别为97.2%和25%，OG组分别为91.9%和23.1%。在33例LAG组和27例OG组无SN转移的患者中，淋巴结转移仅见于与检测到的SN位于同一淋巴盆的非SN。这些数据表明，腹腔镜手术的淋巴盆含有SN的解剖可能是一种有前途的方法，作为一种新型的微创手术的患者与cT 1或cT 2期胃癌没有转移的SN。(Ann外科肿瘤2010年2月17日; Epub提前打印）减