EXPRESSION OF THE TYPE III INOSITOL 1, 4, 5 TRIPHOSPHATE RECEPTOR IS A NOVEL MARKER TO EVALUATE MALIGNANT POTENTIAL IN COLORECTAL CARCINOMA

点击翻译按钮获取中文摘要

The InsP3 receptor (Ca^<2+> signaling) is important for cell proliferation. There are three isoforms of the inositol 1, 4, 5-trisphosphate receptor (InsP3R).In this study, we asked whether each isoform of InsP3R expression is associated with the clinico-pathological futures. METHODS: In 19 paraffin embedded specimens from surgically resected colorectal carcinomas, each isoform of InsP3R and Ki-67 were evaluated by immunohistochernistry. RESULTS: Cytoplasmic expression of type I and type II InsP3Rs were observed in human colorectal mucosa mostly in their apical half. But no type HI InsP3R expression was observed in colorectal mucosa. Meanwhile, all isoforms of InsP3R including type InsP3R were expressed in human colorectal cancer. Type I and type II InsP3R expression was not correlated to clinico-pathological futures including cell proliferation. The type III InsP3R expression was not associated with tumor size, tumor location, disease stage, or cell proliferation but was related to lymph node metastasis (P=0.020). CONCLUSIONS: The type HI InsP3R may be a potential candidate of biomarker for colorectal cancer and a possible therapeutic target for preventing tumor metastasis.