Novel Mechanisms of the Regulation of Reproduction by Novel Brain Hormones
Novel Mechanisms of the Regulation of Reproduction by Novel Brain Hormones
批准号:
18107002
负责人:
TSUTSUI Kazuyoshi
金额:
$68.97万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2010
中文摘要
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英文摘要
We discovered a novel avian hypothalamic neuropeptide inhibiting gonadotropin release, named gonadotropin-inhibitory hormone (GnIH). We demonstrated that GnIH acts on gonadotropes and GnRH neurons via GPR147 to inhibit gonadal development and maintenance by decreasing gonadotropin release and synthesis. We further demonstrated that GnIH has an evolutionarily conserved role in controlling reproduction across vertebrate species.
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The orexigenic effect of GnlH is mediate by central opioid receptors in chicks.
GnlH 的食欲促进作用是由小鸡的中枢阿片受体介导的。
DOI:
--
发表时间:
2008
期刊:
Comp. Biochem. Phvsiol. (in press)
影响因子:
--
作者:
[Kamei Y, Aoyama Y, Fujimoto T, Kenmotsu N, Kishi C, Koushi M, Sugano S, Morohashi K, Kamiyama R, Asakai R., T. Tachibana et al.]
通讯作者:
T. Tachibana et al.
GnlHとGnlH同族ペプチドの多様性と分子進化
GnlH 和 GnlH 同源肽的多样性和分子进化
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Wang, D.S., Kobayashi, T., Zhou, L.Y., Paul-Prasanth, B., Ijiri, S., Sakai, F., Okubo, K., Morohashi, K. and Nagahama, Y, Kondo Y, K. Tsutsui, 筒井和義]
通讯作者:
筒井和義
イモリから同定した新規ニューロステロイドの生理作用
从蝾螈中鉴定出的新神经类固醇的生理作用
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Ohmuro-Matsuyama, Y.et al., Yumiko Saijyo-Hamano, Parhar IS, 筒井和義]
通讯作者:
筒井和義
Gonadotropin-inhibitory hormone (GnIH) in the avian brain
禽类大脑中的促性腺激素抑制激素(GnIH)
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Nagahama, Y., K. Tsutsui]
通讯作者:
K. Tsutsui
DOI:
10.1177/0748730410368821
发表时间:
2010-06
期刊:
Journal of biological rhythms
影响因子:
3.5
作者:
[Mason AO, Duffy S, Zhao S, Ubuka T, Bentley GE, Tsutsui K, Silver R, Kriegsfeld LJ]
通讯作者:
Kriegsfeld LJ
共 185 条
Mechanisms of brain sex differentiation induced by neurosteroids
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批准号:16086206
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$53.76万
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财政年份:2004
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负责人:TSUTSUI Kazuyoshi
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依托单位:
Regulation of the synthesis and release of pituitary hormones by novel hypothalamic neurohormones
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批准号:15207007
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$25.63万
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财政年份:2003
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负责人:TSUTSUI Kazuyoshi
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依托单位:
Role of neurosteroids in the regulation of motivation of instinct behaviors
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批准号:12440233
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.54万
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财政年份:2000
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负责人:TSUTSUI Kazuyoshi
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依托单位:
BIOSYNTHESIS AND ACTION OF NEUROSTEROIDS IN THE BRAIN
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批准号:08454265
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.86万
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财政年份:1996
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负责人:TSUTSUI Kazuyoshi
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依托单位:
Mode of steroid action involving in the behavioral regulation
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批准号:05640749
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1993
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负责人:TSUTSUI Kazuyoshi
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依托单位:
海外基金