Analysis of Common Genetic Factors for Allergy and Infectious Disease in NC Mice

疟疾寄生虫在宿主中的增殖主要由红细胞因子控制，该因子映射到小鼠Chr. 9上的Pymr区域。我们发现了一个令人信服的候选基因，它与脑型疟疾和疟疾肾病间接相关，但对皮炎没有影响。其他有关脑型疟疾（Cmr1，Cmr2）和寄生虫排斥（Pymr2）的遗传位点对皮炎有影响。8号染色体上的Pymr2区域存在一些免疫系统的关键基因，如IL 12rb和IL 27ra1，并且这些基因在NC小鼠中存在一些非同义突变。它们可能作为共同的遗传因子在过敏和感染性疾病的易感性中起作用。

Proliferation of malaria parasites in the host is mainly controlled by an erythrocytic factor that maps to the Pymr region on mouse Chr.9. We found a convincing candidate gene, which was indirectly related to cerebral malaria and malaria nephrosis, but had no effect on dermatitis. Other genetic loci concerning cerebral malaria (Cmr1, Cmr2) and parasite exclusion (Pymr2) had an influence on dermatitis. A few key genes of the immune system, such as Il12rb and Il27ra1, are present in the Pymr2 region on Chr.8, and there were some nonsynonymous mutations in these genes in the NC mice. They may have function as common genetic factors in the susceptibility to allergy and infectious diseases.