Development of an Artificial Synapse using an Integrated Electrochemical Micropump

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The final purpose of this project is a development of integrated micropumps working as an interface between electric circuits and neurons or an artificial synapse. We developed a chip of micropump with microvalve using electrodecomposition of water as a driving force. The chip can control the jetting with punctuality to the second. The pump could induce excitatory postsynaptic potential of Aplysia neuron by neurotransmitter administration. We developed also voltage imaging for central nerve system for evaluation of the ability of the interface. It has been difficult to detect the action potential of Aplysia neuron by voltage imaging. We succeeded in the detection of the action potential by prolonging by tetraethylammonium chloride as a potassium channel blocker. The technologies developed in the project will help the development of neuronal interface by neurotransmitter administration.