Laser Spectroscopic Studies of Non-Covalent Solute-Solvent Interactions Involving Non-Volatile Biomolecules in the Gas Phase

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Solute-solvent interactions play a critical role in determining whether or not many biomolecules display biological activity in solution. Making use of our novel liquid microjet injection technology, we will generate micro-solvated gas phase biomolecules by rapid laser desorption from the surface of a liquid jet (here, micro-solvation describes up to ~10 solvent molecules attached to a solute). Following desorption, laser spectroscopy will be used to directly characterise the non-volatile biomolecular solute-solvent topography. This project will create a new application of laser science to study biophysical and biochemical processes that remain difficult, if not impossible, to explore using traditional techniques.