Research regarding direct actions of perioperative agents on blood vessels of transplantable organs

我们直接调查（即，全身麻醉剂对三个可移植器官肝、肾和小肠的血管的非神经）作用（即，肝动脉、肾动脉和肠系膜动脉）及其潜在机制。为了总结所获得数据的临床相关性，全身麻醉剂异氟烷、七氟烷和依托咪酯可能会在轻度麻醉或去甲肾上腺素给药期间通过其对肠系膜动脉的直接作用减少移植小肠的血流量。然而，它们可能对移植的肝脏或肾脏没有这种有害的血管作用。

We investigated direct (i.e., non-neural) actions of general anesthestics on blood vessels of three transplantable organs liver, kidney, and small intestine (i.e., hepatic, renal, and mesenteric arteries), and their underlying mechanisms. To summarize clinical relevance of the obtained data, general anesthetics isoflurane, sevoflurane, and etomidate may reduce blood flow to the transplanted small intestine through their direct action on mesenteric arteries under light anesthesia or during administration of noradrenaline. However, they probably do not have such an injurious vascular action on the transplanted liver or kidney.