Development of siRNA Gene Therapy in Animal Models of Venous Thromboembolism
静脉血栓栓塞动物模型中siRNA基因治疗的进展
基本信息
- 批准号:18591715
- 负责人:
- 金额:$ 2.44万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2006
- 资助国家:日本
- 起止时间:2006 至 2007
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Orthopedic surgery, especially total knee and total hip arthroplasty, is considered a risk factor for perioperative venous thromboembolism. Our aim of the study was to evaluate how accelerated inflammatogenic cellular interactions and the subsequent production of tissue factor and CD40 ligand play an important role in the pathogenesis of venous thromboembolism. We have demonstrated that platelet, leukocyte and endothelium activities as well as their interactions are enhanced during the perioperative period of total knee arthroplasty, particularly in venous blood from the lower half of the bodies of patients, which consequently augments blood coagulability in the research paper. (J Thromb Haemost.5, 738-45.2007)In the next project, we have demonstrated continuous perioperative milrinone infusion has the potential to prevent accelerated blood cell interactions and hypercoagulablility during the perioperative period of total knee arthroplasty via inhibition of intraplatelet p38 MAPK, 1VIEK/ERK, and PI3K/Akt signaling pathway. These contents will be submitted to the science journal.
骨科手术,特别是全膝关节和全髋关节置换术,被认为是围手术期静脉血栓栓塞的危险因素。我们的研究目的是评估促炎细胞相互作用的加速以及随后组织因子和CD40配体的产生如何在静脉血栓栓塞的发病机制中发挥重要作用。我们已经证明,血小板、白细胞和内皮细胞的活性及其相互作用在全膝关节置换术围手术期得到增强,特别是在患者下半身的静脉血中,从而增强了血液的凝固性。(J血栓血液,5,738 -45.2007)在下一个项目中,我们已经证明,通过抑制血小板内p38 MAPK、1VIEK/ERK和PI3K/Akt信号通路,米力农在全膝关节置换术围手术期持续输注有可能防止加速的血细胞相互作用和高凝性。这些内容将提交给科学杂志。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
PDE3 inhibitor-mediated inhibition of perioperative blood cell activity and hypercoagulability in patients undergoing total knee arthroplasty
PDE3 抑制剂介导的全膝关节置换术患者围手术期血细胞活性和高凝状态抑制
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Beppu;S;Nakajima;Y;et. al.
- 通讯作者:et. al.
Perioperative amino acid infusion improves recovery and shortens the duration of hospitalization after off-pump cornary artery bypass grafting.
围手术期氨基酸输注可改善非体外循环角膜动脉搭桥术后的恢复并缩短住院时间。
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:Umenai T;Nakajima Y et al.
- 通讯作者:Nakajima Y et al.
Predictors of atrial fibrillation after off-pump coronary artery bypass graft surgery
- DOI:10.1093/bja/aem067
- 发表时间:2007-05-01
- 期刊:
- 影响因子:9.8
- 作者:Hosokawa, K.;Nakajima, Y.;Mizobe, T.
- 通讯作者:Mizobe, T.
The change of plasma endothelin-1 levels before and after surgery with or without Down syndrome
唐氏综合征与非唐氏综合征手术前后血浆内皮素-1水平的变化
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Kageyama K;Nakajima Y;et. al.
- 通讯作者:et. al.
PDEIII inhibitorによる血小板機能抑制に関与する細胞内シグナリングについて
PDEIII 抑制剂抑制血小板功能的细胞内信号传导
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:別府 賢;中嶋 康文;他
- 通讯作者:他
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NAKAJIMA Yasufumi其他文献
NAKAJIMA Yasufumi的其他文献
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{{ truncateString('NAKAJIMA Yasufumi', 18)}}的其他基金
Elucidation of the pathology concerning gestational hyprtension by microRNA and its application to gene therapy
microRNA阐明妊娠高血压病理学及其在基因治疗中的应用
- 批准号:
17K11097 - 财政年份:2017
- 资助金额:
$ 2.44万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Elucidation of inflammatory mechanisms by platelet-derived microRNA after cardiac surgery with cardiopulmonary bypass
体外循环心脏手术后血小板衍生的 microRNA 阐明炎症机制
- 批准号:
26462761 - 财政年份:2014
- 资助金额:
$ 2.44万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Elucidation of the intracellular mechanisms concerning monocyte tissue factor production and release, and their applications of the gene therapy
阐明单核细胞组织因子产生和释放的细胞内机制及其在基因治疗中的应用
- 批准号:
20591842 - 财政年份:2008
- 资助金额:
$ 2.44万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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