Development of three types of prostatitis model in rats

前列腺炎是一种以盆腔疼痛和排尿症状为特征的综合征，定义不明确，了解不多，治疗不当，令人烦恼。前列腺炎是初级保健医生和泌尿科医生就诊的常见原因。然而，其发病机制尚不清楚，有效的治疗方法仍有待建立。我们认为有必要开发新的策略，如使用前列腺炎动物模型。目前，还没有可靠的前列腺炎动物模型可用。在本研究中，我们建立了三种不同的前列腺炎动物模型。对于内分泌型，我们注射17β-雌二醇(E_2；250微克/公斤。皮下注射)或注射入大鼠体内30天。感染类型采用大鼠前列腺注射脂多糖(LPS)。对于非特异性炎症类型，我们在大鼠前列腺内注射盐酸。这三种动物模型在膀胱测压图中显示前列腺炎症和膀胱收缩减少。目前的三种模型表现出与人类前列腺炎相似的组织和生理特征。这些动物模型可用于研究前列腺癌的发病机制。

Prostatitis is a syndrome characterized by pelvic pain and voiding symptoms, which is poorly defined, poorly understood, poorly treated and bothersome. Prostatitis is a common cause of visits to primary care physicians and urologists. However, the pathogenesis is largely unknown and the effective treatment remains to be established. We believe that it is necessary to develop new strategy such as using animal model for prostatitis. At present, there are no reliable animal models available for prostatitis. In the present study, we developed three different animal models for prostatitis. For endocrine type, we injected 17 beta-estradiol (E2; 250 microgram/kg. subcutaneously) or vehicle into rats for 30 days. For infections type, we injected lipopolysaccharide (LPS) into rat prostate. For non-specific inflammation type, we injected HC1 into rat prostate. These three animal models demonstrated inflammation in the prostate and decrease intercontraction of the bladder in cystometrogram. The present three models demonstrate histological and physiological features which are similar to prostatitis in human. These animal models could be useful for studying the pathogenesis of prostate.